Patients had their first visit to a doctor for recurrent infection (15/35), abdominal distension (13/35), polypnea due to lactic acid (7/35), hypoglycemia (3/35), acidosis, or hepatomegaly, and some suffered a combination of two or more symptoms. The median age of symptomatic onset ...
Objective To investigate cardiac function in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) and clarify the clinical features of cardiomyopathy in MELAS. Patients 11 consecutive patients with MELAS (mean age at initial examination 11.3 years, range 4 to...
aHYPER LACTIC ACIDOSIS 亢奋乳汁酸中毒[translate] aand we are united! 并且我们被团结![translate] aThe Tribute of Frank Lampard - One Blood, Blue Blood 坦率的Lampard进贡-一血液,名门出身[translate] aAs you write your essay, you should periodically refer to statements in the passage you are discu...
“The animal studies that are used to make the argument provided the animals an excessive amount of polyunsaturated fat, which are antagonistic to the oxidation of sugar and tend to reduce the rate of metabolism, and usually also excessive calories. The special value of fructose is that it can...
It is a severe inherited metabolic disease associated with hypoglycemia, hyperlipidemia, lactic acidosis, hepatomegaly, and neutropenia. Traditional treatment consists of feeding raw cornstarch which can help to adjust energy metabolism but has no positive effect on neutropenia, which is fatal for ...
Further study of the relationship between the molecular clock and MYC in cancer may reveal previously unsuspected vulnerabilities which could lead to new treatment strategies. Keywords: MYC; cancer; circadian rhythm; molecular clock; transcription factor; chromatin; pause release; tumor immunology; ...
PTP1B inhibitors can serve as insulin mimickers, as well as insulin and leptin sensitizing agents [40], therefore making them an attractive option to combat T2D and obesity simultaneously, which represents an advantage over existing therapies to date. However, developing PTP1B inhibitors remains ...
English M, Muambi B, Mithwani S, Marsh K. Lactic acidosis and oxygen debt in African children with severe anaemia. QJM. 1997;90(9):563–9. View ArticleEnglish M, Muambi B, Mithwani S, Marsh K. Lactic acidosis and oxygen debt in African children with severe anaemia. Qjm 1997; 90:...
Li JY, Hsieh RH, Peng NJ, Lai PH, Lee CF, Lo YK, et al. A follow-up study in a Taiwanese family with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes syndrome. J Formos Med Assoc 2007; 106:528-36....
To assess the contribution of acidosis to the observed effects, 5 hearts were treated with acidic Krebs (pH 7.0) for the same time period. To evaluate the role of import of L-lactic acid through monocarboxylate transporter 1 (MCT1) in those effects, additional hearts (n=6) were treated ...