Traditionally, unfractionated heparin (UFH) has been used due to its short half-life in the context of risk of hemorrhagic transformation of the infarct zone. Heparin nomograms and associated bolus dosing are not standardized in clinical practice across centres and patients can exhibit long epochs ...
We aimed to identify attributing factors to the interindividual variabilities of the infusion rates in unfractionated heparin therapy. We included patients who required unfractionated heparin therapy to achieve the target APTT after cardiac surgery betwe
Given the fact that a steady-state drug concentration in the blood is, in general, achieved after 4 or 5 half-lives of drug elimination, for unfractionated heparin with a half-life of 0.5–2 h, the steady state would be reached 2–10 h after treatment initiation14. More importantly, it...
The pharmacological effects of sulodexide differ substantially from unfractionated heparin and are mainly characterized by a prolonged half-life and reduced ... J.,Harenberg - 《Medicinal Research Reviews》 被引量: 162发表: 1998年 Review of pharmacodynamics, pharmacokinetics, and therapeutic properites of...
LMWHs present a number of potential advantages over unfractionated heparin: a longer plasma half-life, improved...doi:10.1016/j.pathol.2016.04.006Lukito, PohanCollecutt, MargaretDauer, RaymondMorgan, SusanTran, HuyenElsevier B.V.Pathology
cells were treated with 10 U/mL unfractionated heparin or saline vehicle as a control. After 2 h of these exposures, the media was aspirated and the slides were washed with iced PBS (GE Healthcare Life Sciences; Logan, UT). Cooled methanol was added to the chamber before incubating fo...
After intravenous administration of low molecular weight heparin, the half-life of the anti-factor Xa activity is considerably longer than for unfractionated heparin, while the anti-factor IIa half-lives are similar. In contrast to unfractionated heparin, low molecular weight heparin is completely ...
The Treatment of Proximal Vein Thrombosis with Subcutaneous Low-Mole Molecular-Weight Heparin Compared with Continuous Intravenous Heparin Low-molecular-weight heparin has a high bioavailability and a prolonged half-life in comparison with conventional unfractionated heparin. Limited data are ... RD Hull,...
21, 22, 23, 24, 25Because UFH, given its short half-life and reversibility, will continue to be a preferred anticoagulant for children, systematic studies on monitoring UFH in children are needed. HEARTCAT (Heparin Anticoagulation Randomized Trial in Cardiac Catheterization) was a parallel-cohort...
Terminal half-life was 54 minutes. Median anti-Xa activities were 0.55 IU/mL at peak, 0.25 IU/mL at end of the 4-hour session, and less than 0.1 IU/mL at 90 minutes after the session. We simulated a continuous infusion of the dose of 50 IU/kg for 1, 2, 3, and 4 hours. ...