Free T4Central hypothyroidism (CH) is a rare cause of hypothyroidism generally related to a hypothalamic鈥損ituitary disorder or arising as an iatrogenic complication. In adults, CH may be secondary to quantitative and/or qualitative alterations in thyroid-stimulating hormone (TSH) secretion. The ...
In more detail, it has been described how patients with MDD tend to have increased levels of thyrotropin (TSH) together with a higher ratio of antithyroid antibodies and elevated levels of thyrotropin-releasing hormone (TRH) in the cerebrospinal fluid [140, 141]. The relationship between the HPT...
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Rats were orally administered DBDPE (5–500 mg/kg bw) for 28 d and found that only FT3 level in serum decreased at the highest dose, accompanied by elevated TSH and TRH levels, and down-regulated genes expression related to TH synthesis in the HPT axis. This showed DBDPE could cause ...
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Inhibition of the type 2 iodothyronine deiodinase underlies the elevated plasma TSH associated with amiodarone treatment Endocrinology, 151 (2010), pp. 5961-5970 CrossrefView in ScopusGoogle Scholar [48] G.R. Williams, J.H. Bassett Deiodinases: the balance of thyroid hormone: local control of ...
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If your TSH is higher than 4.0 mU/L on repeat tests, you probably have hypothyroidism. Your doctor may also order a T4 test. Most of the T4 in your blood attaches to a protein, and when it does, it can’t get into your cells. Only T4 that is unattached or “free” can get into...