Here we review progress leading in 2017 to the medium resolution X-ray structure of DNA-PKcs, a single polypeptide chain of 4128 amino acids. This was followed quickly by chain tracing of cryo-EM structures of DNA-PKcs in complex with Ku and DNA. We discuss how combination of structural ...
We must understand the structure of candida, yeast, and fungi in general to successfully treat the condition. It truly is its own life form being partly vegetative, partly animal, and partly bacterial in nature. It is this ability to adapt and change form, or shape shift, that causes it ...
APOBEC3H (A3H) is a member of the APOBEC3 subfamily of DNA cytosine deaminases that are important for innate immune defense and have been implicated in cancer biogenesis. To understand the structural basis for A3H biochemical function, we determined a high-resolution structure of human A3H and ...
Fig. 3. The structure of Tim44. (A) Cartoon illustration of a secondary structure prediction for the Tim44 N-terminal domain. The presequence is colored purple and the region predicted to bind phospholipids is shown in red. Green arrows point out amino acids suggested to participate in mtHsp...
Gene expression is controlled through the recruitment of large coregulator complexes to specific gene loci to regulate chromatin structure by modifying epigenetic marks on DNA and histones. Metastasis-associated protein 1 (MTA1) is an essential component of the nucleosome remodelling and deacetylase (NuR...
The combination of building blocks determines the organization’s aptitude for execution. Organization DNA is made up of 4 building blocks. These are decision rights and norms, motivation and commitments, information and mindsets, and structure and networks. Complications may come in when compan...
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(the structure of the chambers and valves) are directly causing the global pattern of blood direction and speed. Diffusion is an example of an emergent process because the mechanism is explained by the collective interaction of the dye and water molecules rather than any single or aggregate ...
Determining the structure and mechanisms of all individual functional modules of cells at high molecular detail has often been seen as equal to understanding how cells work. Recent technical advances have led to a flush of high-resolution structures of various macromolecular machines, but despite this...
The chromatin structure of yeast ribosomal DNA was analyzed in vivo by crosslinking intact cells with psoralen. We found that in exponentially growing cult... Dammann,Lucchini,Koller,... - 《Nucleic Acids Research》 被引量: 362发表: 1993年 Systematic analysis of coding and noncoding DNA sequenc...