microbiomexenobioticsOur bodies each possess a unique and dynamic collection of microbes and viruses, collectively the 'microbiome', with distinct metabolic capacities from our human cells. Unforeseen modification of drugs by the microbiome can drastically alter their clinical effectiveness, with the most ...
The human microbiome is a complex and dynamic system that plays important roles in human health and disease. However, there remain limitations and theoretical gaps in our current understanding of the intricate relationship between microbes and humans. In this narrative review, we integrate the knowledg...
The human gut microbiome is a dynamic collection of bacteria, archaea, fungi, and viruses that performs essential functions for immune development, pathogen colonization resistance, and food metabolism. Perturbation of the gut microbiome’s ecological ba
Even though the bacteria of the microbiome are still frequently described as commensal, i.e., neither harmful nor beneficial, their relationship with the human host is often highly mutualistic: at the most basic level, the host provides the bacteria with easy access to food and shelter, while ...
This book discusses the community of microbial species (the microbiota, microbiome), which inhabits the large bowel of humans. Written from the perspective of an academic who has been familiar with the topic for 40 years, it provides a long-term perspective of knowledge about this high profile...
Human studies have also revealed shifts in microbiome signatures in diseased subjects as compared with controls, and a few of them precede the development of these disorders. These studies contribute to pinpointing specific microbiome components and functions (e.g., butyrate-producing bacteria) that ...
Assuming the ultimate goal of most human and mouse microbiome studies is to understand the mechanisms by which microbes influence host health, there are, broadly speaking, two approaches that can be taken with mWGS data. The first is to ask ‘what’s there?’. Establishing the taxonomy of mi...
WoM 2023 Conference will take place 26-28 October 2023 in Sofia, Bulgaria focusing on the significance of the microbiome on the human health.
environment shapes the abundance profile in a given sample, because the metabolic potential of the bacteria indicate which species will thrive in the metabolic environment [52]. To answer this question, GEMs were constructed from annotated reference genomes made available in the human microbiome ...
Despite growing literature characterizing the fecal microbiome and its association with health and disease, few studies have analyzed the microbiome of the small intestine. Here, we examine what is known about the human small intestinal microbiota in terms of community structure and functional properties...