microbiomexenobioticsOur bodies each possess a unique and dynamic collection of microbes and viruses, collectively the 'microbiome', with distinct metabolic capacities from our human cells. Unforeseen modification of drugs by the microbiome can drastically alter their clinical effectiveness, with the most ...
The human microbiome is a complex and dynamic system that plays important roles in human health and disease. However, there remain limitations and theoretical gaps in our current understanding of the intricate relationship between microbes and humans. In this narrative review, we integrate the knowledg...
The human gut microbiome is a dynamic collection of bacteria, archaea, fungi, and viruses that performs essential functions for immune development, pathogen colonization resistance, and food metabolism. Perturbation of the gut microbiome’s ecological ba
Even though the bacteria of the microbiome are still frequently described as commensal, i.e., neither harmful nor beneficial, their relationship with the human host is often highly mutualistic: at the most basic level, the host provides the bacteria with easy access to food and shelter, while ...
WoM 2023 Conference will take place 26-28 October 2023 in Sofia, Bulgaria focusing on the significance of the microbiome on the human health.
As we age, an imbalance of gut microbes can be a source of disease. Because the microbiome is so essential to health, some suggest that the human microbiome should be viewed as a distributed organ performing fundamental functions akin to those of our liver, lungs or kidneys. Alteration to ba...
Assuming the ultimate goal of most human and mouse microbiome studies is to understand the mechanisms by which microbes influence host health, there are, broadly speaking, two approaches that can be taken with mWGS data. The first is to ask ‘what’s there?’. Establishing the taxonomy of mi...
environment shapes the abundance profile in a given sample, because the metabolic potential of the bacteria indicate which species will thrive in the metabolic environment [52]. To answer this question, GEMs were constructed from annotated reference genomes made available in the human microbiome ...
We also thank the many individuals who have participated in our studies, enabling our work on the human microbiome and CRC. Figures were created with https://biorender.com. For funding, this work was supported by Bloomberg Philanthropies, a Cancer Grand Challenges OPTIMISTICC team grant (A27140...
Despite growing literature characterizing the fecal microbiome and its association with health and disease, few studies have analyzed the microbiome of the small intestine. Here, we examine what is known about the human small intestinal microbiota in terms of community structure and functional properties...