high sensitivitysensitivity and specificitytroponinsCardiac troponin (cTn) is a highly specific biomarker of myocardial injury and is central to the diagnosis of acute myocardial infarction (AMI). By itself, ho
The accumulation of H+ lowers the pH, thus potentially interfering with SR Ca2+ release, troponin C sensitivity to Ca2+ and cross-bridge cycling and resulting in impaired muscle force.45 However, the role of decreased pH as an important cause of fatigue is now being challenged.46 Several ...
The demonstration of the molecular targets including TopIIα, TopIIβ, and TopImt which are all related to anthracycline therapy has significant pharmaceutical and clinical implications: First, it provides the rationale for developing TopIIα-specific anticancer drugs to prevent other tissue toxicities ...
Characteristics and in-hospital outcome of patients with no ST-segment elevation acute coronary syndrome and no obstructive coronary artery disease in the era of high-sensitivity troponins. J Cardiovasc Med (Hagerstown). 2019;20(4):210–4. Article CAS PubMed Google Scholar Karakayali M, et ...
1B). The number of patients, which were correctly predicted as true positives, was used to calculate the sensitivity; while the number of healthy, which were correctly predicted as true negative, was used to calculate the specificity for the constructed model. The specificity and sensitivity of ...
high stringency binding of the labeled antisense RNA probe to its target mRNA. The unbound probe is washed away and the embryos are then prepared for binding of an antibody against the label on the RNA probes. Excess antibody is then washed away and an enzymatic color reaction is used...
troponin C sensitivity to Ca2+and cross-bridge cycling and resulting in impaired muscle force.45However, the role of decreased pH as an important cause of fatigue is now being challenged.46Several recent studies have shown that decreased pH may have little effect on contraction in mammalian muscle...
During systole (left), calcium (yellow) is released from sarcoplasmic reticulum and binds troponin (violet). This causes tropomyosin (white) to shift its position and exposes myosin binding sites on actin filament allowing for cross bridge formation. During diastole (right), active calcium uptake ...
This process involves calcium ions that bind to troponin and allow tropomyosin to move away from the myosin-binding sites on actin and ATP, providing the required energy. Therefore, beyond the ion flux (Ca2+ cycling), the bulk energy of the heart is crucial for contraction. AF has been ...
Diabetes mellitus is an important and prevalent risk factor for congestive heart failure. Diabetic cardiomyopathy has been defined as ventricular dysfunction that occurs in diabetic patients independent of a recognized cause such as coronary artery disease or hypertension. The disease course consists of a...