T-cells are also the focus of chimeric antigen receptor (CAR)-based technologies [7] and tumour-infiltrating lymphocyte (TIL) infusion therapy [8,9], two other IO approaches where considerable clinical advances have been made over the last few years. Broadly speaking, there are three main ...
A variety of cells secrete exosomes under both normal and pathological conditions. Exosomes are mainly products of the multivesicular body formed by intracellular lysosomal invagination, and released into the extracellular space by fusion of the outer membrane of the multivesicular body with the cell ...
The AD brains also show evidence of defective lysosomal-mitophagosome fusion and the build-up of damaged mitochondria in autophagic vacuoles [17]. Interestingly, Aβ and p-tau levels show specific associations with different mitophagy markers, suggesting distinct connections between mitophagy failure and...
C. Differential expression of SNAP-25 protein isoforms during divergent vesicle fusion events of neural development. Proc. Natl Acad. Sci. USA 92, 1510–1514 (1995). Article CAS PubMed PubMed Central Google Scholar Bark, C. et al. Developmentally regulated switch in alternatively spliced SNAP...
Synthesis of branched silica nanotrees using a nanodroplet sequential fusion strategy. Nat. Synth. 3, 236–244 (2024). Article CAS Google Scholar Cheng, D. et al. A hierarchical spatial assembly approach of silica-polymer composites leads to versatile silica/carbon nanoparticles. Sci. Adv. 9,...
Nuclear fusion is the release of thermonuclear energy by the conversion of hydrogen nuclei to helium nuclei, in a continuing reaction in the sun and other stars. Nuclear fusion is the principle behind thermonuclear weapons. Attempts to harness fusion for commercial power production have so far not...
These findings confirm Harkins' theory that abundance should depend on nuclear structure; however, they contradict the accepted high hydrogen model of the Sun where fusion of hydrogen is the dominant source of solar energy. Instead, repulsion between like nucleons has been shown as a plausible ...
Is hatched the flowered the enterprise in the growth process, the venture capital function is not allow to neglect, therefore the hypothesized technical hatchibator and the venture capital fusion is advantageous the tendency which develops in the enterprise. [translate] achairman of the board of ...
Fusion, the power that drives the sun and stars, combines light elements in the form ofplasma— the hot, charged state of matter composed of free electrons and atomic nuclei — that generates massive amounts of energy. Scientists are seeking to replicate fusion on Earth for a virtually inexhau...
Finally, an interpretable fusion rule is proposed to fuse the facial and pose features. The fusion algorithm can accurately and stably infer the pedestrians’ intention and identify pedestrians with car-hailing intentions. In order to evaluate the performance of the proposed method, we collected road...