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Several 1-H-pyrazole-3-carboxamide derivatives have been reported to improve the potency and selectivity of FLT3 inhibitors. Among them, the compound known as “50” was selected as the most stable and effective against the D835V and F691L mutations. It can reduce the FLT3 phosphorylation by...
Fouling of maritime infrastructure is pervasive due to abundant biological and chemical activity within the oceanic environment. Marine biofilms and their successional growths are prevalent issues in biofouling, but current industrial and research-based
The N27 MNI template aligned anatomical image and the anatomical mask with white matter and ventricles removed are also available as derivatives/sub<ID>/anat/sub-<ID>_T1w_MNIalignment.nii.gz and derivatives/sub<ID>/anat/sub-<ID>_T1w_mask.nii.gz respectively Functional MRI Locationsub-<ID>...
The burden associated with frequent injections of current intravitreal (IVT) therapeutics may be reduced by long-acting delivery strategies. Binding to serum albumin has been shown to extend the ocular half-life in rabbits, however, the underlying molecu
Environmental applications of chitosan and its derivatives. Rev. Environ. Contam. Toxicol. 2015, 233, 1–43. [Google Scholar] [CrossRef] [PubMed] Kanmani, P.; Aravind, J.; Kamaraj, M.; Sureshbabu, P.; Karthikeyan, S. Environmental applications of chitosan and cellulosic biopolymers: A ...
In general: 1. Changing the amide linkage with ester linkage decreased the antioxidant activity more than most of the amide Leflunomide analogues. 2. The benzimidazole derivatives of Leflunomide 4 and 13 showed higher % of inhibition of radical production than Leflunomide. Benzimidazole derivatives are...