Obstructive sleep apnea (OSA) is a common sleep disorder, characterized by repeated episodes of airway obstruction during sleep resulting in intermittent hypoxemia. Previous studies proposed that reactive oxygen species (ROS) and apoptosis caused by intermittent hypoxia (IH) contributed to cognitive ...
The extrapulmonary complications of COVID-19. SARS-CoV-2 infection has resulted in not only a pulmonary disease but also potentially systematic disease, which may cause long-term multiple organ-system complications including hyperinflammatory syndrome, vascular thrombosis, coagulopathy, cardiovascular, hepat...
Smoking is a common cause of chronic obstructive pulmonary disease (COPD)169. Several lines of evidence suggest that the underlying mechanism could involve promoting CD1-reactive T cell responses. A cigarette smoke-exposed COPD mouse model demonstrated that model mice had elevated CD1d expression by a...
The main risk factor for AD is advanced age [5]. It is believed that the development of the disease is strongly driven by Down’s syndrome, diabetes mellitus type 2, heart disease, hypertension, obesity, and inflammation processes [1]. Genetic mutations appears to be a primary cause of ear...
essential protective roles of reactive astrocytes in traumatic brain injury. brain 129:2761–2772 article cas pubmed google scholar spence rd, hamby me, umeda e et al (2011) neuroprotection mediated through estrogen receptor-alpha in astrocytes. proc natl acad sci u s a 108:8867–8872 article ...
The most well-described cellular responses upon interaction with diesel exhaust are the induction of pulmonary oxidative stress and (pro-)inflammation, both of which are known to be involved in the onset or exacerbation of respiratory diseases such chronic obstructive pulmonary disease (COPD), but al...
s disease [98], systemic lupus erythematosus (SLE) [99,100], rheumatoid arthritis (RA) [101], GvHD [102], Type I diabetes [103] and so on. MSCs also prevent allergic airway inflammation and reduce the symptoms of severe asthma [104,105,106,107,108]. Administration of MSCs functionally...
Although LL-37 constitutes a formidable innate immunity defense barrier against infections, some bacterial species have developed various mechanisms to circumvent its action. An example is the oral pathogenPorphyromonas gingivalisassociated with chronic periodontal disease, which can degrade LL-37 by utilizin...
s disease [98], systemic lupus erythematosus (SLE) [99,100], rheumatoid arthritis (RA) [101], GvHD [102], Type I diabetes [103] and so on. MSCs also prevent allergic airway inflammation and reduce the symptoms of severe asthma [104,105,106,107,108]. Administration of MSCs functionally...
Objective: Diosmetin is a flavonoid that is found in many important medicinal plants that have antihypertensive therapeutic potential. Diosmetin has been shown to have antiplatelet, anti-inflammatory and antioxidant properties, which suggests that it could be a potential candidate for use in antihyperten...