Defective renal excretion and increased production of uric acid engender hyperuricemia that predisposes to gout. However, molecular mechanisms underlying defective uric acid excretion remain largely unknown. Here, we report a rare genetic variant of gout
This finding may be important, as clinical studies have found that delayed cardiovascular recovery from exercise is a significant predictor of mortality in subjects with cardiovascular disease.48,49 Based on our current data, we cannot determine the exact causes of the differences in IAF quantity ...
et al. The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell Metab. 15, 157–170 (2012). Article CAS PubMed PubMed Central Google Scholar Yang, Q. et al. Multiple genetic loci influence serum urate levels and their relationship with gout and...
Goutagny, S. et al. High incidence of activating TERT promoter mutations in meningiomas undergoing malignant progression. Brain Pathol. 24, 184–189 (2014). CAS PubMed Google Scholar Lee, T. I. et al. Control of developmental regulators by polycomb in human embryonic stem cells. Cell 125,...
Atrial fibrillation (AF) is a progressive arrhythmia with underlying mechanisms that are not fully elucidated, partially due to lack of reliable and affordable animal models. Here, we introduce a system for long-term assessment of AF susceptibility (subs
neuronal and synaptic function, increased permeability to inflammatory molecules and disrupted glutamate homeostasis [60]. The present results might indicate that eNOS deficiency and the putative subsequent impairment of BBB permeability may constitute one of the causes underlying MK-801-induced cognitive ...
International Journal of Molecular Sciences Article Effects of Melatonin and Its Underlying Mechanism on Ethanol-Stimulated Senescence and Osteoclastic Differentiation in Human Periodontal Ligament Cells and Cementoblasts Won-Jung Bae 1,†, Jae Suh Park 2,†, Soo-Kyung Kang 3, Il-Keun Kwon 4 ...
Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006, 440, 237–241. [Google Scholar] [CrossRef] [Green Version] Franchi, L.; Amer, A.; Body-Malapel, M.; Kanneganti, T.D.; Ozoren, N.; Jagirdar, R.; Inohara, N.; Vandenabeele, P.; Bertin, J.; ...