These data suggest that cell death is not the primary cause of polyuria in FNDI, and that the aggregate formation in the ER is likely to be related to the pathogenesis of the progressive polyuria. 展开 关键词: diabetes insipidus hereditary disease arginine vasopressin endoplasmic reticulum ...
8 ⅐ No. 7 brief report Novel mutations underlying nephrogenic diabetes insipidus in Arab families Pamela Carroll, BSc1, Hamad Al-Mojalli, MD2, Abbas Al-Abbad, MD2, Ibrahim Al-Hassoun, MD2, Mohamed Al-Hamed, MSc1, Rana Al-Amr, BSc1, Abdul Islam Butt, BSc1, and Brian Francis Meyer...
The finding that mutants of amino acids in AQP2 corresponding to the stick of the swing mechanism cause severe recessive nephrogenic diabetes insipidus (NDI) demonstrates the critical role of the swing mechanism for the aquaporin function. We report first that the inter-subunit hydrophobic interaction...
Degradation of Mutant Proteins, Underlying “Loss of :突变蛋白的降解,潜在的损失OF,of,蛋白,loss,蛋白质,蛋白的,突变的降解,蛋白质的,蛋白质降解,Loss 文档格式: .pdf 文档大小: 594.99K 文档页数: 10页 顶/踩数: 0/0 收藏人数: 0 评论次数: ...