Human & Ecological Risk Assessment An International JournalBeck BD, Clewell HJ. 2001. Uncertainty/safety factors in health risk assessment: opportunities for improvement. Human Ecol Risk Assess 7:203-207.Beck, B.D., Clewell III, H.J., 2001. Uncertainty/safety factors in health risk assessment:...
uncertainty factorsregulatory toxicologyGuidelines have been developed within the Environmental Protection Agency (EPA) for applying uncertainty factors to noncancer risk assessments. In many recent cases, reduced values for uncertainty factors of less than 10 have been used. The specific circumstances that...
The science behind the use of uncertainty factors has progressed considerably. Increased knowledge of inter- and intraspecies sensitivity, mechanisms of action, and detailed evaluation of data bases can support the use of data-derived uncertainty factors, which ultimately results in a risk assessment ...
Uncertainty factors for chemical risk assessment: interspecies differences in glucuronidation 来自 NCBI 喜欢 0 阅读量: 64 作者:K Walton,JL Dorne,AG Renwick 摘要: For the risk assessment of effects other than cancer, a safe daily intake in humans is generally derived from a surrogate threshold ...
Uncertainty factors for chemical risk assessment: interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates... K Walton,JL Dorne,AG Renwick - 《Food & Chemical Toxicology》 被引量: 0发表: 2001年 Uncertainty factors for chemical risk assessment: interspecies ...
The Agency for Toxic Substances and Disease Registry (ATSDR) utilizes chemical-specific minimal risk levels (MRLs) to assist in evaluating public health risks associated with exposure to hazardous substances. During MRL derivation, uncertainty factors (UF) are used. Under current ATSDR methodology, de...
In addition, it argues that uncertainty factors continue to be relevant to efforts to implement the precautionary principle and that the precautionary principle should not be restricted to cases involving unquantifiable hazards. 展开 关键词: Extrapolation Uncertainty factors Safety factors Risk assessment ...
Factors affecting transport sector CO2 emissions growth in Latin American and Caribbean countries: An LMDI decomposition analysis This study determines the factors responsible for the growth of transport sector CO2 emissions in 20 Latin American and Caribbean (LAC) countries during th... GR Timilsina,...
The aim of this study was to investigate how the Scientific Committee on Occupational Exposure Limits (SCOEL) of the European Commission uses uncertainty factors when proposing health-based indicative occupational exposure limit values (IOELVs). In total, 75 IOELVs in 62 summary documents published ...
Human health risk assessments use point values to develop risk estimates and thus impart a deterministic character to risk, which, by definition, is a probability phenomenon. The risk estimates are calculated based on individuals and then, using uncertainty factors (UFs), are extrapolated to the po...