We confirmed the WTC11 line contained no ALS–FTD mutations in the ALS and FTD risk genes in Supplementary Table 1. For key experiments, an independent line was used, NCRM5. NCRM5 was derived from umbilical cord blood from NIH Center for Regenerative Medicine (CRM), Bethesda, MD, USA. ...
However, when tested in vivo (with FUS parameters adjusted to account for the attenuation of ultrasound waves by the skull; see “Methods”), even our lowest-power in vitro optimized AU-FUS parameters [AU1-FUS (in vitro)] still caused weak BBB opening (Supplementary Fig.2). Since neither ...
We thank Dr Guillermo Marques (University of Minnesota Imaging Center) for assistance with image analysis. Author contributions A. H. and M. B. conceptualization; A. H., B. C, D. O., and M. B. methodology; A. H., B. C., and M. B. software; A. H., V. C., M. S., and...
then it will be important to extend the research by undertaking: (a) a comparison of the YES program to a control intervention in a randomized controlled trial, (b) an explanatory study of putative mediators of change, and (c) a multi-center trial with a number of ...