As explained by Wolff’s law and the mechanostat hypothesis, mechanical stimulation can be used to promote bone formation. Low intensity pulsed ultrasound (LIPUS) is a source of mechanical stimulation that can activate the integrin/phosphatidylinositol 3-OH kinase/Akt pathway and upregulate osteogenic...
School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Suzhou 215163, China 4 School of Energy and Power Engineering, Nanjing University of Science and Technology, Nanjing 210094, China ...
Open AccessSystematic Review by Valerio Sveva 1, Giacomo Farì 2, Annatonia Fai 3,*, Alessio Savina 1, Mattia Giuseppe Viva 1, Francesco Agostini 1, Maurizio Ranieri 3, Marisa Megna 3, Massimiliano Mangone 1, Marco Paoloni 1and Andrea Bernetti ...