The success of modern metabolomics analysis depends on the separation of metabolites in complex samples using methods such as LC and mass spectrometry. Herein, we present a protocol for resolving a broad range of polar metabolites, based on hydrophilic interaction LC with a zwitterionic-bonded phase...
Growth of UHPLC-enabled technologies: development of new ultra-high performance liquid chromatography and mass spectrometry technologies has seen dramatic growth in the past decade--and look for even more in the near future.(Cover Story)Studt, Tim...
The forced degradation products were identified using liquid chromatographyelectrospray ionisation-quadrupole time of flight-tandem mass spectrometry (LCESIQTOF–MS/MS) and accurate mass experiments. The in silico toxicities of the degradation products for both the drugs were evaluated. The proposed method...
摘要: Gamma-hydroxybutyric acid (GHB) acts as a precursor and metabolite of the inhibitory central nervous system (CNS) neurotransmitter gamma-aminobutyric acid (GABA). Sodium salt of GH... 查看全部>>关键词: Ultra-high performance liquid chromatography tandem mass spectrometry Gamma-hydroxybutyric ...
2), a structure elucidation of all tentative LOs was done using multiple-stage tandem mass spectrometry. Step 1: suspect list and classification model To create a LO classification model, a suspect list based on literature [14,15,16,17,18, 20] was prepared. The suspect list included 90 ...
The degradation rate constant of tryptophan, in the presence of tyrosine and phenylalanine, was determined. Copyright © 2015 John Wiley & Sons, Ltd.doi:10.1002/jms.3711Kocic, DanijelaAndrew Shalliker, R.Journal of Mass Spectrometry Jms
Australian Centre for Research on Separation Science (ACROSS), School of Science and Health, University of Western Sydney (Parramatta), Sydney, NSW, AustraliaJohn Wiley & Sons, Ltd.Biological Mass SpectrometryKocic D, Shalliker RA (2015) A new approach to live reac- tion monitoring using active...
A fast and simple protein precipitation method followed by short UHPLC chromatography was developed for extraction and separation of vancomycin from plasma. Quantification was performed via heated positive electrospray tandem mass spectrometry with multiple reaction monitoring using deuterated internal standard....
In this study, a highly sensitive and robust method using an ultra-high-performance liquid chromatography-tandem mass spectrometry combined with solid-phase extraction and ultrasonic extraction for pretreatment and silica gel purification steps has been developed for determination of 21 natural and ...
In this work, non-targeted ultra-high performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) fingerprints obtained by C18 reversed-phase chromatography were proposed as sample chemical descriptors for the characterization and classification of turmeric and curry samples. A total ...