UHPLC-HRMS-based metabolomic and lipidomic characterization of glioma cells in response to anlotinib Yingying Shi, Zhuolun Li, Qiuzheng Du, Wenxi Li, Jiyun Liu, Qingquan Jia, Lianping Xue, Xiaojian Zhang & Zhi Sun Scientific Reports volume 13, Article number: 8044 (2023) Cite...
1.UHPLC- 高分辨率 MS 快速测定降解产物采用 UHPLC- 高分辨率 MS 快速分析降解产物。高质量的HRMS 全扫描图谱为测定降解产物的元素组成提供了重要信息,并从随后的数据依赖 MS/MS 获得分子离子的裂解信息。 2.高分辨率 MS/MS 鉴定降解产物的结构 具备阶梯式碰撞能量的高分辨高能碰撞解离功能产生了信息量丰富的碎片...
Determination of BMAA, DAB, AEG and three alkaloid cyanotoxins in lake water using dansyl chloride derivatization and UHPLC-HESI-HRMS detectionWith high-resolution detection using the Q-Exactive mass spectrometer in a fragmentation mode (t-MS2), a highly sensitive and selective detection of BMAA,...
采用UHPLC- 高分辨率 MS 快速分析降解产物。高质量的 HRMS 全扫描图谱为测定降解产物的元素组成提 供了重要信息,并从随后的数据依赖 MS/MS 获得分子离子的裂解信息。 II. 高分辨率 MS/MS 鉴定降解产物的结构 具备阶梯式碰撞能量的高分辨高能碰撞解离功能产生了信息量丰富的碎片,能更轻松地完成降解产物的结构鉴定。
摘要:目的采用超高效液相色谱-四极杆-静电场轨道阱高分辨质谱(UHPLC-Quadrupole-Orbitrap high resolution mass spectrometry,UHPLC-Q-Orbitrap HRMS)技术对6-姜酚在大鼠血浆、尿液和粪便中的代谢产物进行鉴定分析。方法SD大鼠ig给药6-姜...
摘要:目的采用超高效液相色谱-四极杆-静电场轨道阱高分辨质谱(UHPLC-Quadrupole-Orbitrap high resolution mass spectrometry,UHPLC-Q-Orbitrap HRMS)技术对6-姜酚在大鼠血浆、尿液和粪便中的代谢产物进行鉴定分析。方法SD大鼠ig给药6-姜酚羧甲基纤维素钠混悬液后,收集其血浆、尿液、粪便以及胆汁样品。样品前处理后,采...
In this study, screening of the collected 70 Salvia nemorosa L. populations from 54 habitats from West Azerbaijan province, Iran was evaluated by analyzing the content of phytochemical compounds, antioxidant activity, and UHPLC-HRMS profiling in differen
As usual with metabolomic studies through HRMS, limitations to our results are related to the uncomplete annotation of the significantly altered features as well as the lack of authentic standards to confirm the identity of the metabolites, however it must be pointed out that only the features wit...
内容提示: · 430 · Chin J Mod Appl Pharm, 2021 February, Vol.38 No.4 中国现代应用药学 2021 年 2 月第 38 卷第 4 期 UHPLC-Q-Orbitrap HRMS 分析吉马酮大鼠体内代谢产物及代谢途径 英译丹1a ,禹明洋 2 ,肖俊辉 1a ,沈倩 1b (1.南华大学附属第二医院,a.药剂科,b.临床药学科,湖南 衡阳 ...
1 仪器与试药 仪器:UHPLC - Q - Orbitrap HRMS 型液质联用系 统(美国 Thermo Fiser Scientific 公司);Cubis 型电子天平 (德国 Sartorius 公司,精度为百万分之一);98 - Ⅰ - C 型数显控温电热套(湖北泰维科技实业股份有限公司);KQ - 300DE 型超声仪(昆山市超声仪器有限公司, 功率为 300 W,频率为 40 ...