UDP-N-acetylglucosamine 2-epimeraseN-acetylmannosamine kinase… 文档格式: .pdf 文档大小: 950.2K 文档页数: 7页 顶/踩数: 0/0 收藏人数: 0 评论次数: 0 文档热度: 文档分类: 论文--期刊/会议论文 文档标签: UDP-N-acetylglucosamine2-epimeraseN-acetylmannosaminekinase ...
英文别名: UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing)中文名: 中文别名: CBNumber: CB87251935 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 2 UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing)化学性质
BACKGROUND: UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) is a key molecule in the pathogenesis of distal myopathy with rimmed vacuoles (DMRV) and hereditary inclusion body myopathy (HIBM) and almost all such patients have some mutations in GNE. However, subcellular localiz...
Early invasive growth and metastasis are features of pancreatic cancer that rely on its resistance to anoikis, an apoptosis program activated on loss of matrix anchorage. How anoikis is regulated is unclear. UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine-kinase (GNE) was silenced, or p1...
Overproduction of NeuAc is believed to result from loss of feedback inhibition of uridinediphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) by cytidine monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac). We report the cloning and characterization of human UDP-GlcNAc 2-epimerase ...
Currently, more than 60 different mutations spread over the whole gene are known [2], [3]. The UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE) is the key enzyme of sialic acid biosynthesis [4]. Sialic acids (Sia) represent a family of amino sugars with over 50 ...
UDP- N -acetylglucosamine 2-epimerase/ N -acetylmannosamine kinase ( EC5.1.3.14 /2.7.1.60), the key enzyme of N -acetylneuraminic acid biosynthesis ... S Hideo,H Akira,N Toshihiro,... - 《Yakugaku Zasshi-journal of the Pharmaceutical Society of Japan》 被引量: 28发表: 1984年 Metabolis...
GNE, NT (GNE, GLCNE, Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UDP-GlcNAc-2-epimerase/ManAc kinase, UDP-N-acetylglucosamine 2-epimerase, UDP-GlcNAc-2-epimerase, Uridine diphosphate-N-acetylglucosamine-2-epimerase, N-acet ...
In an in vitro UDP-GlcNAc 2-epimerase assay, Lec3 cells had no detectable UDP-GlcNAc 2-epimerase activity, and Lec3 cells grown in serum-free medium were essentially devoid of sialic acid on glycoproteins. The Lec3 phenotype was rescued by exogenously added N-acetylmannosamine or mannosa...
Hereditary inclusion body myopathy and distal myopathy with rimmed vacuoles are both caused by mutations of the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) gene. Here we report a Japanese patient with compound heterozygous missense mutations in the epimerase domain of GNE gen...