According to conserved domains identified in their amino acid sequences, these glycosyltransferases can be classified into a single UDP-glycosyltransferase (UGT) 1 superfamily. We performed genome-wide comparative analysis of UGT genes to trace evolutionary history in algae, bryophytes, pteridophytes, ...
The UDP-glycosyltransferase (UGT) superfamily expressed in humans, insects and plants: Animal–plant arms-race and co-evolution Karl Walter Bock* Department of Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Wilhelmstrasse 56, D-72074 Tübingen, Germany A R T I C L...
Uridine diphosphate glycosyltransferases (UDP-glycosyltransferase, UGTs), belonging to the family 1 of the glycosyltransferase superfamily, catalyze sugar transfer from UDP-activated sugar donors to various substrates. Plant genomes contain a large number of UGTs. For example, 122 UGT genes have been ide...
UDP-glycosyltransferase (UGT) is an important biotransformation superfamily of enzymes. They catalyze the transfer of glycosyl residues from activated nucleotide sugars to acceptor hydrophobic molecules, and function in several physiological processes, including detoxification, olfaction, cuticle formation, pigmen...
3). The corresponding homology of Arabidopsis, AtUGT73Bs, belongs to Group D of the UGT superfamily (Ross et al., 2001). A previous in vitro analysis demonstrated that AtUGT73B1 and AtUGT73B2 preferentially transferred a glucose group to the flavonoid 7-OH group and 3-OH group, ...
(Tb927.7.290) and a thioestherase-like superfamily protein (Tb927.7.330), but theT. vivaxcontig containing the former does not span the UGT gene. Similarly, lineage 6 locus seems conserved in all three species, being delimited by a methyltransferase domain containing protein (Tb927.10.12270)...
The UDP glycosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence. Pharmacogenetics 1997, 7, 255–269. [Google Scholar] [CrossRef] [PubMed] Bock, K.W. Vertebrate UDP-glucuronosyltransferases: functional and evolutionary aspects. Biochem. Pharmacol. 2003, 66...
Meech R, Miners JO, Lewis BC, Mackenzie PI. The glycosidation of xenobiotics and endogenous compounds: Versatility and redundancy in the UDP glycosyltransferase superfamily. Pharmacology & Therapeutics. 2012;134(2):200-218Meech R, Miners JO, Lewis BC and Mackenzie PI: The glyco‑ ...
UDP-glycosyltransferasemicroRNAdrug metabolismgene regulationpolymorphismThe human UGT gene superfamily is divided into four subfamilies (UGT1, UGT2, UGT3 and UGT8) that encodes 22 functional enzymes. UGTs are critical for the metabolism and clearance of numerous endoge......
PromoterTransgenic tobaccoGlycosyltransferasePanax quinquefoliusGlycosyltransferases, a multigene superfamily in plants, are necessary to synthesize, modify and diversify specific ginsenosides in Panax quinquefolius. P. quinquefolius is widely used in medicine and nutrition. Various glycosyltransferases catalyze ...