The UDP-glycosyltransferase (UGT) superfamily expressed in humans, insects and plants: Animal-plant arms-race and co-evolution. Biochem. Pharmacol. 2015, 99, 11-17. [CrossRef]Bock KW. The UDP-glycosyltransferase (UGT) superfamily expressed in humans, insects and plants: Animal-pla...
invertebrates and plants mainly with glucose. Plant–herbivore arms-race has been the major driving force for evolution of large UGT and other enzyme superfamilies. The UGT superfamily is defined by a common protein structure and signature sequence of 44 amino acids responsible for binding the ...
UDP-dependent glycosyltransferases (UGTs) be- long to the largest family (family 1) of the glycosyltrans- ferase superfamily and present distinct but overlapping substrate specificities [5]. For the nomenclature system, UGT genes are named using the UGT Nomenclature Committee conventions: the root ...
The UGT superfamily is defined by a common protein structure and signature sequence of 44 amino acids responsible for binding the UDP moiety of the sugar donor. Plants developed toxic phytoalexins stored as glucosides. Upon herbivore attack these conjugates are converted to highly reactive compounds...
UDP-glycosyltransferase (UGT) is an important biotransformation superfamily of enzymes. They catalyze the transfer of glycosyl residues from activated nucleotide sugars to acceptor hydrophobic molecules, and function in several physiological processes, including detoxification, olfaction, cuticle formation, pigmen...
A unique signature motif has been identified in the amino acid sequence of many of these glycosyltransferases leading to their classification into a single UGT (UDP GlycosylTransferase) superfamily (2). Of these, the mammalian UGTs using UDP- glucuronic acid have attracted considerable attention in ...
Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the α-d-phosphohexomutase superfamily Article Open access 27 March 2020 Shedding of N-acetylglucosaminyltransferase-V is regulated by maturity of cellular N-glycan Article Open ...
6). MurG is a member of the GT-B superfamily of enzymes (family 28) that are metal-independent inverting glycosyltransferases (27, 29). Structural studies on the complex between the E. coli MurG and UDP-GlcNAc have revealed key conserved residues in the C-terminal half of the enzyme that...
(Tb927.7.290) and a thioestherase-like superfamily protein (Tb927.7.330), but theT. vivaxcontig containing the former does not span the UGT gene. Similarly, lineage 6 locus seems conserved in all three species, being delimited by a methyltransferase domain containing protein (Tb927.10.12270)...
It should be emphasized that at least six cloned UDP-GlcNAc N-acetylglucosaminyltransferases are not sufficiently homologous to be included as members of this superfamily and may represent an example of convergent evolution. For naming each gene, it is recommended that the root symbol UGT for ...