22, 46, 6) with only one gene, the scaffold1 with two genes, scaffold18 and scaffold51 each with three genes, scaffold14 and scaffold56 each with four genes, and scaffold15 and 25 each with five genes (Fig.2). Among these genes, 16 genes are located in the positive...
The gene families associated with the detoxification of these compounds are essential for the adaptive evolution of insect defensive strategies. However, knowledge on uridine diphosphate (UDP)-glycosyltransferases (UGTs) of X. quadripes is unavailable. Here, we characterized 30 UGT genes identified from...
To further investigate selection pressure on the evolution of AhUGTs, the ratio of Ka and Ks for duplicated gene pairs was calculated. As a result, the Ka/Ks values of 61 tandem (98.39%) and 91 segmental duplicated pairs (91.92%) were less than 1, indicating that majority of AhUGTs ...
However, other gene(s) of the UGT1 family were expressed in the perivenous region surrounding the central veins as detected by hybridisation with the probe against the common region of the UGT1 genes. Treatment with the lower dose (5 mg/kg) of 3-methylcholanthrene (3MC) induced expression...
These findings from this comparative study of two lepidopteran UGTs as well as other insects reveal a diversity comparable to this gene family in vertebrates, plants and fungi and show the magnitude of the task ahead, to determine biochemical function and physiological relevance of each UGT enzyme....
The butterfly plant arms-race escalated by gene and genome duplications Coevolutionary interactions are thought to have spurred the evolution of key innovations and driven the diversification of much of life on Earth. However, ... PP Edger,HM Heidel-Fischer,M Bekaert,... - 《Proc Natl Acad ...
Results: We performed genome-wide comparative analysis of UGT genes to trace evolutionary history in algae, bryophytes, pteridophytes, and angiosperms; then, we further investigated the expansion mechanisms and function characterization of UGT gene families in Brassica rapa and Brassica oleracea. Using...
alba gene specific primers were designed using PerlPrimer (v1.1.21) (Table S1) to amplify either corresponding cDNA or approximately 2 kb (1.6–2.1 kb depending on the gene) DNA region upstream of the start codon. The different UGT72s’ coding and promoter sequences were then cloned in ...
Yamamoto K, Sato H, Fujiyama Y, Doida Y, Bamba T: Contribution of two missense mutations (G71R and Y486D) of the bilirubin UDP glycosyltransferase (UGT1A1) gene to phenotypes of Gilbert’s syndrome and Crigler-Najjar syndrome type II. Biochim Biophys Acta 1998, 1406: 267–273....
The GLT8D1 gene was also found associated with psychiatric disorders such as schizophrenia10. Its expression was decreased in the hippocampus of schizophrenia patients and evidence indicated its involvement in the pathophysiology of the disease11. GLT8D1 is also associated with cancer: a mutation ...