Biosynthesis of the glycosaminoglycan precursor UDP-α-D-glucuronic acid occurs through a 2-fold oxidation of UDP-α-D-glucose that is catalysed by UGDH (UDP-α-D-glucose 6-dehydrogenase). Structure-function relationships for UGDH and proposals for the enzymatic reaction mechanism are reviewed in ...
The crystal structure of an extremely thermostable UDP-glucose dehydrogenase (UDP-GDH) from the hyperthermophilic archaeon Pyrobaculum islandicum was determined at a resolution of 2.0 Å. The overall fold was comprised of an N-terminal NAD+ dinucleotide binding domain and a C-terminal UDP-sugar ...
The primary structure of bovine liver UDP-glucose dehydrogenase (UDPGDH), a hexameric, NAD+-linked enzyme, has been determined at the protein level. The 52-kDa subunits are composed of 468 amino acid residues, with a free N-terminus and a Ser/Asn microheterogeneity at one position. The seq...
N -glycans may inhibit protein aggregation, may increase resistance to proteolytic degradation, and may promote acquisition of elements of secondary structure such as turns (Chen et al. 2010). Of particular relevance is the involvement of N -glycans in glycoprotein folding in the ER (Caramelo and...
The solubility properties, composition, and structure of the radioactive product synthesized from UDP-[14C]glucose by a highly active cotton fiber glucan synthetase have been determined. Product obtained under the following three different conditions was analyzed: at high and low substrate concentrations...
UDP-glucose-isoflavone 7-O-glucosyltransferase structure CAS No. Chemical Name: UDP-glucose-isoflavone 7-O-glucosyltransferase Synonyms UDP-glucose-isoflavone 7-O-glucosyltransferase CBNumber: CB31384106 Molecular Formula: Molecular Weight: 0 MDL Number: MOL File: Mol file Request For ...
To validate our findings, we analyzed metabolite responses using a mathematical theory called structural sensitivity analysis (SSA), in which the responses of concentrations in reaction systems to perturbations in enzyme activity are determined from the structure of the network alone. A comparison of ...
UDP-glucose 4,6-dehydratase structure CAS No. 68189-53-7 Chemical Name: UDP-glucose 4,6-dehydratase Synonyms UDP-glucose 4,6-dehydratase CBNumber: CB57251707 Molecular Formula: Molecular Weight: 0 MDL Number: MOL File: Mol file Request For QuotationSuppliers 2 ...
2005, Structure Citation Excerpt : Based on sequence similarity to known enzymes, a pathway leading to the synthesis of lipid A-Ara4N has been proposed (Figure 1) (Baker et al., 1999; Breazeale et al., 2002, 2003, 2005; Zhou et al., 1999). Conversion of UDP-Glucose into UDP-Glucuron...
ternatea by UDP-glucose:anthocyanidin 3-O-glucosyltransferase (Ct3GT-A; AB185904). To elucidate the structure-function relationship of Ct3GT-A, ... T Hiromoto,E Honjo,T Tamada,... 被引量: 0发表: 2013年 加载更多来源期刊 Planta 研究点推荐 Flower color 引用走势 2011 被引量:9 站内...