Uridine diphosphate-α- d -glucose 6-dehydrogenase (UGDH, EC 1.1.1.22) is the four-electron transfer enzyme responsible for the oxidation of 6-hydroxyl group of UDP-α- d -glucose (UDP-Glc) to produce UDP-α- d -glucuronic acid (UDP-GlcA). The latter is the substrate for numerous ...
翻译结果1复制译文编辑译文朗读译文返回顶部 UDP-葡萄糖脱氢酶,推测[蓖麻] 翻译结果2复制译文编辑译文朗读译文返回顶部 UDP 葡萄糖 6-dehydrogenase,推定 ( Ricinus communis) 翻译结果3复制译文编辑译文朗读译文返回顶部 UDP-葡萄糖 6-脱氢酶,指认 [蓖麻] 翻译结果4复制译文编辑译文朗读译文返回顶部 udp-葡萄糖6-率...
Biosynthesis of UDP-glucuronic acid by UDP-glucose 6-dehydrogenase (UGDH) occurs through the four-electron oxidation of the UDP-glucose C6 primary alcohol ... S Egger,A Chaikuad,M Klimacek,... - Encyclopedia of Hydrological Sciences 被引量: 1发表: 2011年 UDP-Glucose 6-Dehydrogenase Knockout...
Computational methods were used to investigate both the physical and chemical properties of UDP-glucose 6-dehydrogenase (hUGDH). Secondary structure analysis of the query model was done using the Self-Optimized Prediction method With Alignment (SOPMA), the secondary structure predict...
inUDP-Glucose 6-Dehydrogenase(UGDH), which changes alanine into valine at position 44 of the UGDH protein, was the only segregating candidate variant. TheUGDHp.A44V missense affects a highly conserved residue (Suppl. Fig.1band phyloP 100-way8score 9.43), is extremely rare in public databases...
Biosynthesis of the glycosaminoglycan precursor UDP-α-D-glucuronic acid occurs through a 2-fold oxidation of UDP-α-D-glucose that is catalysed by UGDH (UDP-α-D-glucose 6-dehydrogenase). Structure-function relationships for UGDH and proposals for the enzymatic reaction mechanism are reviewed in ...
Locus of the catalytic sites of udp-glucose dehydrogenase in the native enzyme hexamer as delineated by fluorescence energy transferdoi:10.1016/s0006-3495(80)84940-xFranzen, James S.Marchetti, PaulFeingold, David S.Elsevier BVBiophysical Journal...
UDP-glucose dehydrogenase (UDPGDH; EC 1.1.1.22) belongs to a small family of NAD+-linked oxidoreductases which transfer four electrons per catalytic cycle. Other examples of four-electron-transferring enzymes include histidinol dehydrogenase, β-hy-droxy-ß-methylglutaryl-CoA reductase, and other nu...
UDP-glucose-6-dehydrogenase (UGDH) plays an important role in the production of hyaluronic acid, an extracellular matrix component that is responsible for the promotion of normal cellular growth and migration. Increased levels of UGDH have been linked to the progression of epithelial cancers, such ...
Pagni M , Lazarevic V , Soldo B and Karamata D ( 1999 ) Assay for UDPglucose 6-dehydrogenase in phosphate-starved cells: gene tuaD of Bacillus subtilis 168 encodes the UDPglucose 6-dehydrogenase involved in teichuronic acid synthesis . Microbiology , 145 , 1049 – 1053 ....