UDCA is now widely used in the treatment of primary biliary cirrhosis (PBC) but its mechanism of action is poorly understood. We investigated the effects of UDCA on biliary secretion of endogenous GSH. [METHODS] UDCA was administered i.v. to male Sprague-Dawley rats treated with acivicin ...
UDCA(优思弗)治疗脂肪性肝病的临床疗效观察 硕士生姓名:刘林 指导教师:王英德教授 指导小组:唐海英教授 专业名称:内科学 摘要 目的:脂肪性肝病是一种日益多发的慢性肝脏疾病。本研究采用熊去氧胆酸 (商品名:UDCA优思弗)治疗脂肪性肝病患者,观察熊去氧胆酸治疗脂肪性肝 病的疗效,包括临床症状、肝功能、血脂及影像学变...
The mechanism for this step is analogous to the mechanism for ketal or acetal formation except sulphur replaces oxygen as the nucleophile attacking the carbonyl group. In a second step, the dithioketal is reduced to the corresponding methylene compound by hydrogenolysis in presence of Raney Nickel...
In the search for a mechanism of action that could explain the beneficial effects exerts by the combination of the BAR502 and UDCA we have carried out a detailed analysis of the composition of bile acid pool. Conversion of cholesterol in to bile acids is a major mechanisms of cholesterol disp...
Moreover, UDCA is also considered as an active agent with antiapoptotic and cytoprotectant activity, because it can prevent cytochrome c release, caspase activation and cleavage of poly (ADP-ribose) polymerase. In addition to the aforementioned mechanism, UDCA has been reported to help inhibit ...
However, the mechanism how these proteins are removed from their lipid platform remains unclear. The question arises, whether the proteins are removed primarily or the structure of the DRM-PM, per se, is disrupted. The latter is supported by the detergent-like character of the bipolar UDCA-LPE...