for the site-specific delivery of the drug (28). It is known that aminopeptidase activity increases from the ligament of Treitz to the distal ileum (28-31). Among the host of brush border peptidases, aminopeptidase A, in particular, is able to ...
While development of single drug treatments has been the main strategy in the last decade, the fact that a large proportion of these approaches have failed to meet pre-specified endpoints52 strongly support the notion that treating NASH requires the development of combinatorial approaches. Building ...