UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic targetUBR5AKTN-end rule ubiquitinationLung adenocarcinomaInteractionBackground: N-end rule ubiquitination pathway is known to be disrupted in many diseases, including cancer. UBR5, an E3 ...
UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy. The N-end rule pathway is a proteolytic system in which destabilizing N-terminal residues of short-lived proteins act as degradation determinants (N-degron...
Song, Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases. Nat. Struct. Mol. Biol. 17, 1175-1181 (2010). Medline doi:10.1038/nsmb.1907W. S. Choi, B.-C. Jeong, Y. J. Joo et al., "Structural basis for the recognition of N-end ...
但是,我们也可能希望它们是纯文本而不是标签。我们可以通过提供标签来实现这一点 label.box = FALSE。 SCpubr::do_DimPlot(sample = sample,label = TRUE,label.box = FALSE) Change the color of the label text. 但是,我们可以进一步处理函数的其他参数,如label.color将为标签和标签内的文本提供不同的颜色,...
UBR4, a member of the UBR box E3 ubiquitin protein ligase family, is necessary for the post-translational regulation of eukaryotic proteins [29]. Previous studies have reported that UBR4 is associated with proteasomal degradation, apoptosis, autophagy, yolk sac development and muscle hypertrophy [30...
第1步 上傳UBRL文件 從您的計算機、Google Drive、Dropbox、URL 或通過將它們拖到頁面上來選擇文件。 第2步 選擇MAT 選擇輸出MAT或任何其他格式作為轉換結果(單擊轉換按鈕) 第3 步 下載您的 UBRL 文件 轉換後,您可以下載 MAT 文件並將其上傳到 Google Drive、Dropbox。
UBR4 is a member of the N-terminal recognition fam- ily, whose conservative UBR box domain recognizes the n-terminal residues of substrate proteins and acts as an E3 ubiquitin ligase to degrade the substrate proteins via the ubiquitin-proteasome pathway [38]. The ubiquitin- proteasome system, ...
The presence of dipeptides inhibitors of N-degron recognition sites (Nillegoda et al., 2010) or the N-terminal UBR box deletion in Ubr1 (Wang et al., 2022) did not affect the degradation of misfolded proteins. Although more evidence should be presented, our data hinted that UBR1 function...
The UBR box is sufficient for recognition of type-1 residues, whereas the N-domain, which is structurally similar to the bacterial ClpS protein, is required for the recognition of type-2 residues [8], [9]. The UBR box is conserved among all UBR family proteins, but its function, ...
第1步 上傳UBRL文件 從您的計算機、Google Drive、Dropbox、URL 或通過將它們拖到頁面上來選擇文件。 第2步 選擇YCBCRA 選擇輸出YCBCRA或任何其他格式作為轉換結果(單擊轉換按鈕) 第3 步 下載您的 UBRL 文件 轉換後,您可以下載 YCBCRA 文件並將其上傳到 Google Drive、Dropbox。