2006. Yeast UBL-UBA proteins have partially redundant functions in cell cycle control. Cell Division 1:28. doi: 10.1186/1747-1028-1-28Diaz-Martinez, L.A., Kang, Y., Walters, K.J., and Clarke, D.J. (2006). Yeast UBL-UBA proteins have partially redundant functions in cell cycle ...
弓形虫存在泛素-蛋白酶体系统,但尚无关于UBL-UBA穿梭蛋白的研究报道,因此本研究对该家族蛋白的功能及其作用机制进行研究.通过制备多克隆抗体并进行间接免疫荧光实验(IFA),发现弓形虫表达三种UBL-UBA穿梭蛋白且均定位于虫体胞质和胞核.应用CRISPR/Cas9技术,分别构建单基因缺失株,两两基因缺失株和三基因缺失株.比较研究...
Huang ShengkaiLi YanYuan XinghuaZhao MeiWang JiaLi YouLi YuanLin HongZhang QiaoWang WenjieCell Death & DifferentiationHuang S, Li Y, Yuan X, et al. The UbL-UBA Ubiquilin4 protein func- tions as a tumor suppressor in gastric cancer by p53-dependent and p53-independent regulation of p21...
根据实验数据显示，使用UBL进行投放，创编时间缩短3/4，车系ARPU提升50%+；使用UBA可以实现30%的跑量能力提升，同游戏roi提升可达20%。在手动投放链路中，巨量广告升级版也提升了基础的自动化应用水平，通投智选、Nobid（最大转化出价）、CBO（预算择优分配）、账户优选起量等单点自动化能力，可以有效帮助投手优化...
Members of the UbL-UBA domain-containing protein family have been implicated in different biological functions, such as nucleotide excision repair (29, 30), spindle pole body duplication (31), and protein degradation (32, 33, 34). Notably, the Rad23 and PLIC2 proteins have been reported to ...
There are three UBL-UBA containing proteins in budding yeast: Ddi1, Dsk2 and Rad23, which have been demonstrated to play regulatory roles in targeting ubiquitinated substrates to the proteasome for degradation. An involvement of these proteins in cell cycle related events has also been reported. ...
The UBL‐UBA shuttle protein family, which escorts the ubiquitinylated proteins to the proteasome for degradation, are crucial components of UPS. Here, we identified three UBL‐UBA shuttle proteins (TGGT1_304680, DNA damage inducible protein 1, DDI1; TGGT1_295340, UV excision repair protein ...
Defective binding of ubiquitinated and UBL-UBA proteins to Rpn10ΔUIM/ΔRpn13 proteasomes.Jun, Hamazaki
KPC2 contains a ubiquitin-like (UBL) domain, two ubiquitin-associated (UBA) domains, and a heat shock chaperonin-binding (STI1) domain. We now show that KPC2 interacts with KPCI through its UBL domain, with the 26S proteasome through its UBL and NH2-terminal UBA domains, and with poly...
Ubiquilin4 (Ubqln4), a member of the UbL-UBA protein family, serves as an adaptor in the degradation of specific substrates via the proteasomal pathway. However, the biological function of Ubqln4 remains largely unknown, especially in cancer. Here, we reported that Ubqln4 was downregulated in ...