Ubiquitin – Proteasome-Dependent Proteolysis in Cancer and Septic RatsVoisinTaillandierObled
Overall, this study demonstrates that starvation down-regulates the ubiquitin-proteasome pathway, possibly highlighting differences in the regulation of protein turnover in poikilothermic and endothermic animals. 展开 关键词: Polyubiquitin Proteasome Proteolysis Oncorhynchus mykiss Gene expression ...
Misfolded, aggregated, or surplus proteins are efficiently degraded via distinct protein degradation pathways, including the ubiquitin-proteasome system, autophagy, and vesicular trafficking. These pathways are regulated by covalent modification of target proteins with the small protein ubiquitin and are ...
Genomic alterations may make cancer cells more dependent than normal cells on mechanisms of proteostasis, including protein folding and degradation. This proposition is the basis for the clinical use of proteasome inhibitors to treat multiple myeloma and mantle cell lymphoma. However, proteasome inhibitors...
Selective proteolysis in Arabidopsis thaliana: Dissecting the transcriptional regulation of the Ubiquitin/26S proteasome system Proteins tagged with Ub chains are then recognized by the 26S proteasome, an ATP-dependent protease that cleaves the target into smaller polypeptides that ... NP Gladman 被引...
Human embryonic stem cells (hESCs) exhibit high levels of proteasome activity, an intrinsic characteristic required for their self-renewal, pluripotency and differentiation. However, the mechanisms by which enhanced proteasome activity maintains hESC ide
(IKK) which phosphorylates inhibitory IκBs, leading to the separation of IκBs from NF-κB and the dissociation of IκBs via the ubiquitin-proteasome dependent pathway [26]. Stimulated NF-κBs migrate into the nucleus, bind to the DNA consensus, and activate the expression of target genes...
proteasome also block antigen presentation, most probably by inhibiting proteolysis of the antigen (ovalbumin). Thus, it appears that processing of MHC restricted class I antigens requires both ubiquitination and subsequent degradation by the proteasome. It is likely that the proteasome catalyzes ...
RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis J. Cell Sci., 117 (2004), pp. 281-292 View in ScopusGoogle Scholar [33] B. Bingol, C.F. Wang, D. Arnott, D. Cheng, J. Peng, M. Sheng Autoph...
The ubiquitin/proteasome-dependent proteolysis system has been implicated in a wide variety of cellular regulatory mechanisms, including transcription, signal transduction, and cell cycle control (reviewed in [1]). The system employs a cascade of enzymatic reactions that lead to the covalent attachment...