Ubc-CreERT2小鼠是一种在泛素C(Ubiquitin C, Ubc)启动子下驱动Cre重组酶的转基因小鼠模型,其中Cre重组酶与一种被称为ERT2的改良型雌激素受体配体结合域融合。这种设计允许研究人员通过外源添加的激素(如他莫昔芬)来时间和空间上精确控制Cre重组酶的活性,从而实现目标基因的条件性敲除或激活。 关于Ubc-CreERT2小鼠...
(2015) Differential organ phenotypes after postnatal Igf1r gene conditional deletion induced by tamoxifen in UBC-CreERT2; Igf1r fl/fl double transgenic mice. Transgenic Research 24 , 279-294 Online publication date: 1-Apr-2015. /Icíar Paula López , Lourdes Rodriguez-de la Rosa , Rosete ...
We investigated the effects of decreased sumoylation in adult mammals by generating mice with an inducible knockout (by injection of 4-hydroxytamoxifen) of the E2 enzyme Ubc9 ( Ubc9fl/-/ROSA26-CreERT2 mice). We analyzed the phenotypes using a range of histologic techniques. Loss of Ubc9...