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Herpes simplex viruses are large, enveloped, DNA viruses with a genome of approximately 152 kilobase (kb) pairs. Genetically modified HSV are attractive as replication-competent, oncolytic vectors for a number of reasons. For example, multiple genes can be deleted and/or replaced with therapeutic ...
The numbers in parentheses represent the sizes of the upstream fragments in kilobase pairs. These fragments and a fragment containing the human β-globin gene were inserted into the plasmid vector pCV001. HSI, II (13) β and HS I (7.0)β were derived from the HS I-V (22)β cosmid ...
grouped according to amino acid homology among the PRDs of their PspA proteins. This is the first time, to our knowledge, that PRDs have been characterized in this fashion: revealing three PRD Groups. Group 1: bold italic typeface; Group 2: bold typeface; Group ...