Here I investigated whether the receptor protein tyrosine phosphatase (RPTP) LAR, which is known to modify the activity of several RTKs, also regulates platelet derived growth factor (PDGF) receptor activity and signalling. Mouse embryonic fibroblasts (MEFs) expressing m...
the normal density of excitatory synapses and dendritic spines depend on (i) tyrosine phosphatase activity of LAR-RPTP, (ii) protein interactions mediated by the LAR D2 domain (the binding site of liprin-伪), (iii) endoproteolytic cleavage of LAR and (iv) protein interactions mediated by the...
To test the role of the leukocyte common antigen-related protein tyrosine phosphatase (LAR) as a regulator of insulin receptor (IR) signalling, an siRNA probe against LAR was developed. Knock-down of LAR induced post-receptor insulin resistance with the insulin-induced activation of PKB/Akt and...
产品名称: LAR Protein Tyrosine Phosphatase (LAR) .0 订购此产品 供应商: NEB 规格: 200 U 目录价: ￥:1329 库存状态: CAS编号: 应用范围: 种属来源: 相关信息: 保存条件: 说明书地址: 点击查看详细 打印此页 关闭此页 上一个:T7 Express Competent E.coli(High Effic.)[C2566H/20tubes]...
Protein tyrosine phosphatases (PTPs) are pivotal regulators of key cellular functions, including cell growth, differentiation, and adhesion. Previously, we reported that leukocyte common antigen-related (LAR) tyrosine phosphatase promotes osteoblast differentiation in MC3T3-E1 preosteoblast cells. In the ...
Low molecular weight protein tyrosine phosphatase (LMWPTP) has a single catalytic domain (Figure 2) with an approximate molecular weight of 18 kDa. It is the sole class II PTP member, and its overall sequence and 3D structures are different from the aforementioned higher molecular weight PTPs,...
Protein tyrosine phosphatases (PTPs) are pivotal regulators of key cellular functions, including cell growth, differentiation, and adhesion. Previously, we reported that leukocyte common antigen-related (LAR) tyrosine phosphatase promotes osteoblast differentiation in MC3T3-E1 preosteoblast cells. In the ...
Moreover, the siRNA probe provides a molecular tool of general applicability for further dissecting the precise targets and roles of LAR. 展开 关键词: Insulin receptor Protein tyrosine phosphatase LAR Protein kinase B MAP kinase Insulin resistance ...
The laminin–nidogen complex is a ligand for a specific splice isoform of the transmembrane protein tyrosine phosphatase LAR. J. Cell Biol. 141, 1675–1684 (1998). Article CAS PubMed PubMed Central Google Scholar Brady-Kalnay, S. M., Flint, A. J. & Tonks, N. K. Homophilic binding ...
Expression of the receptor-linked protein tyrosine phosphatase LAR: proteolytic cleavage and shedding of the CAM-like extracellular region. EMBO J. 1992;11:897–907. Article CAS PubMed PubMed Central Google Scholar Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, et al...