上海玉博生物科技有限公司 主要致力于“JAK2(Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2) 蛋白质酪氨酸激酶JAK-2抗原 yb-0908P”的生产销售。多年的“JAK2(Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2) 蛋白质酪氨酸激酶JAK-2抗原 yb-0908P”生产与
Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide corresponding to amino acids 475 to 491 of mouse JAK2, a member of the Janus kinase (Jak) family of cytoplasmic protein tyrosine kinases.
The protein tyrosine kinase JAK2 is activated in neutrophils from patients with severe congenital neutropenia. Blood. 1995;86(12):4500-5Rauprich P, Kasper B, Tidow N, Welte K. The protein tyrosine kinase JAK2 is activated in neutrophils from patients with severe congenital neutropenia. Blood. (...
Janus kinase 2 (JAK2) has an essential role in the signaling of normal hematopoiesis. The somatic JAK2V617F activating mutation is found in 50–60% of patients with primary myelofibrosis [206]. Fedratinib is an oral, potent JAK2 inhibitor showing activity against wild-type and mutation...
产品名称:JAK2(Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2)蛋白质酪氨酸激酶JAK-2抗原 .0订购此产品 供应商:国产 规格:PACK 目录价:询价 库存状态: CAS编号: 应用范围: 种属来源: 相关信息: JAK2(Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2)蛋白质酪氨酸激酶JAK-2抗原 ...
Discovered roughly 10 yr ago, Jak2 tyrosine kinase has emerged as a critical molecule in mammalian development, physiology, and disease. Here, we review th
JAK (Januskinase) is a kind of protein tyrosine kinase, so far it has found of four family members, namely JAK1, JAK2, TYK2 and JAK3. The first three are widely distributed in various kinds of tissue cells while JAK3 can only be found in the bone marrow and lymphatic system. STATs ...
Also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src. 1 publications A10053 Tyrphostin AG 879 HER2 inhibitor Tyrphostin AG 879 is an inhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA. A10062 Allitinib tosylate (AST-1306 TsOH, AST-6) ...
Examples of such oncogenic translocations include the fusion of the dimerization domain of an ETS-family transcription factor to a Jak-family tyrosine kinase in the leukemogenic Tel-Jak2 fusion,30 and the fusion of the oligomerization domain of nucleophosmin with the tyrosine kinase domain of ALK ...
The JAK2 point mutation may contribute to the development of these diseases, and the elucidation of the cellular function of mutated JAK2 might facilitate the development of a suitable drug. In numerous cases, the effects of a mutationally altered protein on cellular functions like proliferation, ...