图一:JAK1蛋白结构。图片来源:SWISS-MODEL。 JAK1靶点介绍 >蛋白功能 >蛋白表达 >蛋白定位 >异构体 & 翻译后修饰 WB实验贴士 >注意事项 >阳性对照 >结果示例 >关键控制点 参考文献 JAK1靶点介绍 蛋白功能 非受体型酪氨酸激酶,参与IFN-alpha/beta/gamma信号通路。 白细胞介素(IL)-2受体以及白细胞介素(IL)...
We have produced a cell line which lacks the protein tyrosine kinase JAK1 and is completely defective in interferon response. Complementation of this mutant with JAK1 restored the response, establishing the requirement for JAK1 in both the interferon-& alpha;/& beta; and -& gamma; signal ...
产品编号: bs-1439P 查看说明书 产品名称: JAK1(Tyrosine-protein kinase JAK1; Janus kinase 1)蛋白质酪氨酸激酶JAK-1抗原 .0 订购此产品 供应商: 国产 规格: PACK 目录价: 询价 库存状态: CAS编号: 应用范围: 种属来源: 相关信息: JAK1(Tyrosine-protein kinase JAK1; Janus kinase 1)蛋白质...
TYROSINE-PROTEIN KINASE JAK1 结构式图片 扩展信息 VIP试用医疗器械查询APP下载客服中心常见问题数据可视化数据分析挖掘系统网站地图业务介绍友情链接 400-678-0778 投诉热线: (023) 6262 8397 邮箱: tousu@yaozh.com QQ: 236960938 友情链接: 药物在线 药品注册查询 临床试验查询 参比制剂目录 康...
Protein tyrosine kinase JAK / signal transducer and transcription activator STAT signaling pathway is another important kind of cytokine signaling pathways after the discovery of Ras pathway. JAK (Ja
Brepocitinib (PF-06700841) 是JAK1和TYK2双重抑制剂,IC50分别为 17 nM 和 23 nM。它抑制JAK2和JAK3的效果较弱,IC50分别为 77 nM 和 6.49 μM 。 规格价格库存数量 1 mg¥ 283现货 5 mg¥ 662现货 10 mg¥ 1,070现货 25 mg¥ 1,980现货 ...
PROTEIN KINASE CHUMAN PLATELETSInterferon-gamma (IFN-gamma) induces the expression of a set of early response genes by tyrosine phosphorylation of latent transcription factors such as p91. Although the tyrosine kinases, Jak1 and Jak2, have recently been shown to be critical for signal transduction ...
JH1 is the kinase domain important for the enzymatic activity of the JAK and contains typical features of a tyrosine kinase such as conserved tyrosines necessary for JAK activation (e.g. Y1038/Y1039 in JAK1, Y1007/Y1008 in JAK2, Y980/Y981 in JAK3, and Y1054/Y1055 in Tyk2). 对于...
Sorafenib is an oral multi-kinase inhibitor approved for patients with advanced renal cell carcinoma and hepatocellular carcinoma34 with potent activity against several receptor tyrosine kinases involved in tumour progression and tumour angiogenesis.35 Ruxolitinib is instead a selective JAK inhibitor recently...
Summary: The Janus family kinases (Jaks), Jak1, Jak2, Jak3, and Tyk2, form one subgroup of the non-receptor protein tyrosine kinases. They are involved in... K Ghoreschi,A Laurence,JJ O'Shea - 《Immunological Reviews》 被引量: 1581发表: 2010年 Reactive Nitrogen Intermediates Promote Low...