D.M. Collins, K. Gately, C. Hughes et al., "Tyrosine kinase inhibitors as modulators of trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity in breast cancer cell lines", Cell Immunol, vol. 319, pp
1C). In common with other tyrosine kinase fusion genes, Sptbn1-Flt3 is constitutively active and transforms Ba/F3 cells to IL-3 independence. We demonstrated that the SPTBN1-FLT3 transformed cell lines are a useful means to compare the potencies of different inhibitors and, in particular, ...
Here, we analyzed the effect of tyrosine kinase inhibitors (TKIs) on the localization of the FLT3 receptor and its mutants. TKI treatment increased the surface expression through upregulation of FLT3 and glycosylation of FLT3-ITD and FLT3-D835Y mutants. In T cell-mediated cytotoxicity (TCMC) ...
The tyrosine kinase inhibitor (TKI) Sunitinib is one the therapies approved for advanced renal cell carcinoma. Here, we undertake proteogenomic profiling of 115 tumors from patients with clear cell renal cell carcinoma (ccRCC) undergoing Sunitinib treatment and reveal the molecular basis of differential...
Tyrosine kinases are implicated in tumorigenesis and progression, and have emerged as major targets for drug discovery. Tyrosine kinase inhibitors (TKIs) inhibit corresponding kinases from phosphorylating tyrosine residues of their substrates and then bl
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. Tyrosine kinase inhibitors (TKIs) remain the backbone of systematic therapy for advanced hepatocellular carcinoma. Sorafenib and lenvatinib are currently approved as fi
Tyrosine kinases are implicated in tumorigenesis and progression, and have emerged as major targets for drug discovery. Tyrosine kinase inhibitors (TKIs) inhibit corresponding kinases from phosphorylating tyrosine residues of their substrates and then bl
Tyrosine Kinase Inhibitors Abstract Gliomas are the most common primary brain tumour diagnosed in adults. Glioblastoma multiforme, the most aggressive grade of glioma, is the most frequent. Despite current treatment with a combination of surgery, radiation and chemotherapy, median survival of patients ...
Tyrosine kinase inhibitors ctDNA: Circulating tumor DNA exoNA: Exosomal nucleic acid exoTNA: Exosomal total nucleic acid cfDNA: Cell-free DNA BAL: Bronchoalveolar lavage ddPCR: Droplet digital PCR NAs: Nucleic acids LOD: Limit of detection NGS: Next-generation sequencing ...
Kinase Inhibitors and Kinase-Targeted Cancer Therapies: Recent Advances and Future Perspectives 2024, International Journal of Molecular Sciences Machine learning-based ultrasomics for predicting response to tyrosine kinase inhibitor in combination with anti-PD-1 antibody immunotherapy in hepatocellular carcinoma...