网络酪氨酸激酶活性 网络释义 1. 酪氨酸激酶活性 细胞膜上具有酪氨酸激酶活性(tyrosine kinase activity)的跨膜蛋白受体在细胞内信号转导中起着较为重要的作用。该激酶活性启 … cdmd.cnki.com.cn|基于 1 个网页 释义: 全部,酪氨酸激酶活性
Tim van BiesenJohn Wiley & Sons, LtdCurrent protocols in pharmacologyHawes BE, van Biesen T. Protein tyrosine kinase activity assays. Current protocols in pharmacology / editorial board, Enna SJ. 2001;Chapter 3:Unit3 5. doi: 10.1002/0471141755.ph0305s05 PMID: 21965067....
tyrosine kinase (redirected fromTyrosine kinases) Medical n. Any of a family of enzymes that phosphorylate tyrosine in certain proteins and play an important role in cell signaling. Mutations that affect their activity or expression can cause leukemia and other cancers. ...
Deregulated tyrosine kinase activity has been observed in many proliferative diseases (e.g., cancer, psoriasis, restenosis, etc.). Tyrosine kinases are, therefore, attractive targets for the design of new therapeutic agents against cancer. We have built up a pharmacophore model of the ATP-b...
For example, the protein tyrosine kinase activity of Src is activated when its SH2 domain binds to tyrosine autophosphorylation sites on PDGFR (94, 105). Similarly, binding of p85, the regulatory subunit of PI-3 kinase, to phosphotyrosines in the PDGFR or IRS1 causes conformational changes in...
et al. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res. 56, 100–104 (1996). CAS PubMed Google Scholar Heinrich, M. C. et al. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine...
Tyrosine-kinase activity in rabbit platelets stimulated with platelet-activating factor : The effect of inhibiting tyrosine kinase with genistein on platel... The temporal relationship of tyrosine phosphorylation of proteins in platelet-activating-factor-(PAF)-stimulated rabbit platelets was characterised by...
Protein tyrosine kinase (PTK) activity was assayed in cytosolic extracts from normal breast tissue, benign tumors, and 84 T1-T2, N0-N1 M0, breast carcinomas. Normal breast tissue extracts yielded an average value of 1.9 +/- 1.1 pmol 32P incorporated/min/mg protein, whereas a mean of 12.5...
EGFR tyrosine kinase activity and Rab GTPases coordinate EGFR trafficking to regulate macrophage activation in sepsis Xuedi Zhang, Cuiping Chen, Chunxiu Ling, Shuhua Luo, Ziying Xiong, Xiaolei Liu, Chaoxiong Liao, Pengyun Xie, Youtan Liu, Liangqing Zhang, Zhanghui Chen, Zhife...
R7, R8 and R9 are each independently selected from organic and inorganic substituents, their use in therapy of diseases, in particular diseases mediated by the tyrosine kinase activity of Janus kinases, including JAK-2 and JAK-3 kinases.Inventors...