Olanzapine and clozapine increased mPFC HA efflux in a dose related manner. Increased HA efflux was also observed after quetiapine, chlorpromazine, and perphenazine treatment. We found no effect of the selective 5-HT2Aantagonist MDL100907, 5-HT2cantagonist SB242084, or the 5-HT6antagonist Ro 04-...
Clozapine had intermediate extrapyramidal effects similar to those of chlorpromazine but it produced hypersalivation and dose-related sedation. Thus, risperidone had advantages over the other antipsychotics used in this study because it did not produce salivation, had minimal extrapyramidal effects and ...
Moreover, certain medications within this class, such as clozapine, require careful monitoring due to rare but serious side effects like agranulocytosis, which is a severe decrease in white blood cell count.6 List of Atypical Antipsychotics Examples of atypical antipsychotics6include these commonly pr...
Olanzapine and clozapine increased mPFC HA efflux in a dose related manner. Increased HA efflux was also observed after quetiapine, chlorpromazine, and perphenazine treatment. We found no effect of the selective 5-HT2A antagonist MDL100907, 5-HT2c antagonist SB242084, or the 5-HT6 antagonist Ro...
Importantly, the same effect is produced in intact male rats by clozapine (Buckland et al, 1997). Clinical studies reported that raloxifene, a second generation selective estrogen receptor modulator, mimics 17b-estradiol effect on 5HT2A receptor binding by increasing 5HT2A receptor binding levels ...
Odds ratios for EPS and numbers needed to harm [number of patients who would need to be treated to obtain one more case with an adverse outcome (i.e. EPS) as compared with the control treatment (clozapine)] were calculated to obtain risk estimates for 15 different antipsychotics. RESULTS: ...
Serum BDNF was strongly and positively correlated with clozapine dose ( r = 0.643; p = 0.002) but not with other demographic characteristics. These results reinforce previous findings of reduced serum BDNF levels in schizophrenic patients and suggest a differential effect of clozapine compared to ...
Acute administration of clozapine (20 mg/kg, i.p.) markedly increased c-fos mRNA expression in deep layers of the infralimbic and ventral prelimbic cortex (IL/vPL); however, a single dose of haloperidol (1 mg/kg, i.p.) was significantly less effective. Like clozapine, remoxipride (0.3 ...
Switch from neuroleptics to clozapine does not influence pituitary–gonadal axis hormone levels in male schizophrenic patients Hypothalamic dopaminergic and serotonergic inputs participate in the regulation of pituitary hormones, and drugs that block central dopamine and serotonin ......
() Citation Context ...esis is further authenticated by the fact that atypical neuroleptics (clozapine, risperidone, zotepine) administered to animals either do not cause any similar changes in the expression of enkephalin =-=[3, 4, 13, 43, 45]-=-, substance P and dynorphin [40, 45] ...