The degree of binding of a drug to a receptor can be measured directly by the use ofradioactivelylabeled drugs or inferred indirectly from measurements of the biological effects of agonists andantagonists. Such measurements have shown that the followingreactiongenerally obeys thelaw of mass actionin...
c, Cluster heat map of Spearman correlations of the cell type basis matrix column space derived from Tabula Sapiens. Color bar denotes correlation value. d, Mean fractional contributions of cell-type-specific RNA in the plasma cell-free transcriptome (n = 18 patients). e, Top tissues in...
reported using enzymes instead of fluorescein-labeled antibodies to develop the enzyme-labeled antibody approach (Enzyme-labeled antibody technique) for the localization and identification of antigens in biological tissues, respectively. Engvall Van Weemen et al. published the enzyme-labeled immunosorbent ...
To cross most of these barriers, the drug must be able to move through the lipid layer of the cell membrane. Drugs that are highly lipid-soluble do this readily; hence, they are rapidly absorbed from the intestine and quickly reach most tissues of the body, including the brain. They ...
Cell therapy has emerged as a viable approach for treating damaged organs or tissues, particularly with advancements in stem cell research and regenerative medicine. The innovative technique of cell sheet engineering offers the potential to create a cell-dense lamellar structure that preserves the extrac...
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Nat. Med. 27, 546–559 (2021). Article CAS PubMed PubMed Central Google Scholar Cheng, J. B. et al. Transcriptional programming of normal and inflamed human epidermis at single-cell resolution. Cell Rep...
Since the thyroid gland is controlled by the pituitary gland and hypothalamus, disorders of these tissues can also affect thyroid function and cause thyroid problems. What are the specific kinds of thyroid disorders? There are specific kinds of thyroid disorders that include: Hypothyroidism Hyperthyroidi...
Since the thyroid gland is controlled by the pituitary gland and hypothalamus, disorders of these tissues can also affect thyroid function and cause thyroid problems. What are the specific kinds of thyroid disorders? There are specific kinds of thyroid disorders that include: Hypothyroidism Hyperthyroidi...
of reticular fibers, which is somewhat confusing since these are not considered "collagen fibers" like the fibers made from type I are; types I and III are often seen together in tissues. Type IV is found in basement membranes, while type V is seen in hair and on the surfaces of cells...
of all previous annotations. Thirdly, the incompleteness of the current knowledge and researcher subjectivity may contributes to cells mislabeling7,8. Lastly, transferring annotations between independent datasets generated by different research groups studying related tissues is challenging, often resulting in...