if miRNAs implicated in a specific tumor phenotype, their target genes will be aberrantly regulated, Xu et al.4 con- structed a miRNA-target dysregulated network (MTDN) by integrating target prediction results and expression profiles data of miRNA and mRNA that in tumor and non-tumor tissues....
1 | Identification of asthma subgroups through topic modeling. a Flowchart of asthma subgroup identification. The MarketScan data includes around six mil- lion asthma patients who have at least one comorbid disease (CD). To enable the estimation of sample statistics, we randomly selected one ...
Low-fat, low-glycemic load diet and gene expression in human prostate epithelium: a feasibility study of using cDNA microarrays to assess the response to dietary intervention in target tissues. Cancer Epidemiol Biomarkers Prev. 2007;16(10):2150–4. Article CAS PubMed Google Scholar Bergstrom A...
We found that tip-like ECs mainly exist in tumor tissues but barely exist in normal tissues. Tip-like ECs are involved in the promotion of tumor angiogenesis and inhibition on anti-tumor immune responses. Moreover, tumor cells, myeloid cells, and pericytes are the main sources of pro-...
Among the strengths of the current study are the size of the sample and that the gym members were located in all the regions of the KSA. In addition, the findings of this study provide information regarding the most common sites/soft tissues liable to injury. It also builds knowledge of ...
which is a significant limitation. This underlines the need for further studies with larger samples. In addition, since MIBI is not a thyroid -specific molecule and has the affinity for a number of tissues with high mitochondrial content, it is still not widely accepted in the routine diagnostic...
Flowchart of experimental design. This describes the steps in the process of identifying dengue virus reactive proteins by 2D VOPBA to facilitate picking the relevant spots from a gel run under identical conditions and at the same time as those which were used for electrotransfer to nictrocellulose...
As single-cell identity is lost in bulk tissues, we introduce the average total UMI counts per cell for each cell type. To allow for inter-patient comparisons and remove potential technical artifacts still contained in the UMI count measure, we further introduce the ratio of the average total ...
An outstanding challenge of epigenome-wide association studies (EWASs) performed in complex tissues is the identification of the specific cell type(s) responsible for the observed differential DNA methylation. Here we present a statistical algorithm called CellDMC (https://github.com/sjczheng/EpiDISH...
The CpG island methylation frequency of miR-34b in hepatocellular carcinoma cancer (HCC) is significantly higher in the tumor cells compared with that in adjacent non-tumor tissues, which may correlate to the inactivation of miR-34b in HCC115. MiR-34c is predicted to be related to prostatic ...