This chapter explores the origins and the types of stem cells. The understanding of stem cells made a great leap forward in the 1960s by the discovery that teratocarcinomas, tumors that form spontaneously in the testes of some strains of mice, can be propagated indefinitely by repeated ...
Hair follicles, mammalian mini-organs that grow hair, miniaturize during aging, leading to hair thinning and loss. Here we report that hair follicle stem cells (HFSCs) lose their regenerative capabilities during aging owing to the adoption of an atypical
In the age of stem cell engineering it is critical to understand how stem cell activity is regulated during regeneration. Hairs are mini-organs that underg... Plikus,Maksim,V.,... - 《Nature》 被引量: 374发表: 2008年 Fully functional hair follicle regeneration through the rearrangement of ...
A.Although all cell types can divide, only stem cells differentiate after division.B.Stem cells are able to divide to produce populations of cells that differentiate into a related set of cells.C.Stem cells divide asymmetrically to give rise to one daughter cell that remains a stem cell, and...
necrotizing enterocolitis, stem cell, intestine, injuryBackgroundNecrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in premature infants. Increased intestinal permeability is central to NEC development. We have shown that stem cells (SC) can reduce the incidence and severity ...
Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. We extend this concept to identify cell types of origin using the Tabula Sapiens transcriptomic cell atlas as well as individual tissue transcriptomic cell atlases in combination with the Human Protein Atlas RN...
In the damaged lung, different epithelial cells can self-renew and differentiate, depending on the region and type of injury18. In the mouse trachea and main bronchi, basal cells are considered the major stem cell population19. Lineage tracing of Scgb1a1+ cells demonstrated that club cells act...
Preclinical Evaluation of Adult Stem Cell Engraftment and Toxicity in the CNS of Rhesus Macaques Congenital neurodegenerative diseases exhibit progressive postnatal neurologic impairment leading to premature death and are intractable to systemic therap... Iryna,A.,Isakova,... - 《Molecular Therapy》 被引...
As a result, we report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggests a coherent model of cell dynamics enabling unarrested growth. This model relies on spatially-restricted stem, progenitor and differentiated populations in the epithelial and mesenchymal ...
Three types of interstitial stem cell subpopulation were isolated from Hydra magnipapillata, and their roles in sex determination were examined. A subpopulation of interstitial stem cells restricted to the sperm differentiation pathway was isolated previously from strain nem-1 (male). Another subpopulatio...