Recently, miR-1307-3p was found to be a cancer-related microRNA. We evaluated the expression levels of miR-1307-3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ...
Solid tumors are heterotypic aggregates of many cell types, including cancer cells, cancer stem cells, connective-tissue cells, and immune cells. All of these cells can communicate with one another via specific junctions (tight and gap junction) that maintain and regulate a perfect tumor microenvir...
Patient-derived tumor xenograft(PDX) models of GC closely retain the... Haiyong,Wang,Jun,... - 《Bmc Cancer》 被引量: 4发表: 2017年 Experimental models of pediatric brain tumors. Establishment, immunophenotyping and clinical implications. Brain tumors are the most common solid tumors in ...
We observed distinct transcriptional contributions from solid tissue-specific cell types from the intestine, liver, lungs, pancreas, heart, and kidney (Fig. 1d and Extended Data Fig. 4). Altogether, the observation of contributions from many non-hematopoietic cell types underscores the ability to ...
FOXO1 might play the role of an oncogenic gene in LGG and OV, while playing the role of a cancer suppressor gene in KIRC. FOXO1 expression had a significant correlation with the infiltration of some immune cells in LGG, OV, and KIRC. By combining FOXO1 expression and immune cell ...
Transcriptional heterogeneity among malignant cells of a tumor has been studied in individual cancer types and shown to be organized into cancer cell states; however, it remains unclear to what extent these states span tumor types, constituting general f
Integrative clustering further emphasized the dominant role of cell-of-origin patterns. Molecular similarities among histologically or anatomically related cancer types provide a basis for focused pan-cancer analyses, such as pan-gastrointestinal, pan-gynecological, pan-kidney, and pan-squamous cancers, ...
Breast cancerEribulinTumor microenvironmentRecently, the concepts of progression due to pre-existing lesions (PPL) and progression due to new metastasis (PNM) have been proposed to differentiate the progression types of treatment-resistant cancers. Previously, the differences between these two progression ...
et al. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 121, 823–835 (2005). Article CAS PubMed Google Scholar Guha, A., Deshpande, A., Jain, A., Sebastiani, P. & Cardoso, W. V. Uroplakin 3a(+) cells are a distinctive population of epithelial ...
Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment Article Open access 04 November 2022 Cancer-associated fibroblasts are associated with poor prognosis in solid type of lung adenocarcinoma in a machine learning analysis...