Lipids—chieflyfats,phospholipids, andsteroids—are major structural components of the human body. Fats provide an energy reserve for the body, andfatpads also serve as insulation and shock absorbers. Phospholipids and the steroidcompoundcholesterolare major components of the membrane that surrounds each...
which are opioid peptides such asenkephalinsthat are produced by the body. Those substances block the reception of pain stimuli by binding to neural receptors that activate the pain-inhibiting neural pathway. That system can be activated by stress or shock and is probably responsible for the absen...
HSP27 is a small, ubiquitous heat shock protein that belongs to the group of molecular chaperones, which respond to various environmental stresses. HSP27 has been found to be overexpressed in various types of cancers [102,103], where it works as a balance regulator between cell death and ...
In the world of data acquisition, we measure AC voltages and currents, shock and vibration, temperature, strain, pressure, and the like. These signals and sensors require sample rates in the range of DC to 200,000 samples per second (200 kS/s) on average, while a few applications require...
For example, we examined the gene expression levels of Hspa1a, which encodes a stress-inducible heat shock protein. At the DGE level, as mentioned above, Hspa1a was found to be upregulated in aging and downregulated in RJV in ECs (Supplementary Tables 3 and 4). To verify this change, ...
In the absence of ligands, the glucocorticoid receptor (GR) is retained in the cytoplasm through complexation with heat-shock protein HSP90. Upon ligand binding, GR is able to dissociate from HSP90 and is then imported into the nucleus in NLS-dependent fashion [81]. The tumor-suppressor p53...
There is a need to define regions of gene activation or repression that control human kidney cells in states of health, injury, and repair to understand the molecular pathogenesis of kidney disease and design therapeutic strategies. Comprehensive integration of gene expression with epigenetic features ...
The shock wave from the supernova explosion that destroyed the Kepler will reach this systems sun in less than three star-dates, and it is 100 percent probable that it will initiate a chain reaction nova. And the nova will destroy all life in the star system. All oceans will boil away;...
Advanced designs of Sound Level Meters are very popular in both the industrial sector, and for health related measurements. End users want items that are both mobile and easy to use. These products come complete in one battery operated hand-held unit that does not require any assembly f...
Similarly, BRD4 was not required for the transcription of genes that bear CCAAT boxes and a TATA box (including histone genes and LTR12 retrotransposons) or for the induction of heat-shock genes. This categorization of enhancers through cofactor dependencies reveals distinct enhancer types that can ...