Phase III trials The experimental study drug or treatment is given to large groups of people. Researchers confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the experimental drug or treatment to be used safely. III期试验:...
Clinical trials are broken down into phases, with each phase having a different purpose within the trial. Phase I trials involve a small group of people (20-80) and are concerned with determining a safe dose of the drug being studied as well as its potential side effects. In Phase II, t...
Broadly, the safety of a medicine is tested in four phases, each of which produces different types of data: pre-clinical (animal) studies, human volunteer studies (Phase I), clinical trials (Phases II and III) and post-marketing surveillance (Phase IV). The principles of these are outlined...
Identifying pathogenic variants from the vast majority of nucleotide variation remains a challenge. We present a method named Multimodal Annotation Generated Pathogenic Impact Evaluator (MAGPIE) that predicts the pathogenicity of multi-type variants. MAG
However, the xenolith-based studies usually show that lithospheric mantle evolves through a sequence of multiple melt depletion and metasomatic events. The mantle peridotite xenolith suites can be grouped in two classes with this respect: In this study we describe xenolith suites which belong to the...
Study on the form partitioning and content of heavy metals in soil particles with different sizes is crucial for preventing and controlling heavy metals pollution, but few studies regard soil contaminated by heavy metals as a homogeneous body. In this study (Fig. 1), goat manure, lime and phos...
Phase variation in Mycobacterium tuberculosis glpK produces transiently heritable drug tolerance. Proc. Natl Acad. Sci. USA 116, 19665–19674 (2019). Article CAS PubMed PubMed Central Google Scholar Heunis, T. et al. Proteogenomic investigation of strain variation in clinical Mycobacterium ...
264–274, Plates 1–4 [referred to as the motile “Crystallolithus” phase of Coccolithus pelagicus (Wallich) Schiller]; Nishida, 1979, Plate 3, Fig. 1b, c (referred to as the motile phase of C. pelagicus); Heimdal & Gaarder, 1980, Plate 2, Fig. 13. Cells are globose to sub...
When training the network after pre-training, after several studies to debug the parameters in order to make the CNNs iterate faster during the training process, the parameters were set as follows: the number of iterations was 120; the computational batch size was 4; the optimizer was Adam; ...
Most of these models fairly capture the structure of observed biological spikes, but have difficulties in incorporating biological features, such as neuronal response failures in the intermittent phase38 and dynamical changes in the neuronal response latency39,40, both mainly attributed to the dendrites...