Long-acting insulin analogs release insulin as a steady amount over most of the day, without any noticeable peak in insulin levels, mimicking natural basal insulin release.They are preferred over intermediate-acting insulins (NPH insulin) because they have a longer duration of action, flatter ...
Pens:Similar to a syringe, an insulin pen uses a needle to inject the medicine into your body. But pens are prefilled with insulin, so you don’t need to fill them from a bottle. Some insulin pens are disposable, while others can be reused by inserting a new cartridge of insulin. Pen...
Insulin detemir is associated with more predictable glycemic control and reduced risk of hypoglycemia than NPH insulin in patients with type 1 diabetes on a basal-bolus regimen with premeal insulin aspart. Diabetes Care. 2003;26(3):590-596. doi:10.2337/diacare.26.3.590PubMedGoogle Scholar...
We definitely like that in terms of basal insulin, things have really evolved. First, we had NPH [neutral protamine Hagedorn], which had a peak and made it more likely to have hypoglycemia. Then, we developed glargine and detemir, but we know those don’t always last 24 hours. Like you...
Regular insulin (Humulin®Novolin®NPH insulinIn 2008, the Centers for Disease Control and Prevention (CDC) estimated that 24 million people in the United States had diabetes mellitus, constituting nearly 8% of the population. The CDC further estimated that 57 million individuals were affected ...
Comparison of once-daily insulin detemir with NPH insulin added to a regimen of oral antidiabetic drugs in poorly Controlled Type 2 Diabetes Background: Many patients with poorly controlled type 2 diabetes mellitus (DM) receive, as initial insulin treatment, the addition of a basal formulation t...
This study was performed to evaluate the composition of the extracellular matrix of the mesangium in both diabetic and nondiabetic rats. Four groups of rats (n = 10 each) were studied. Nondiabetic rats were injected with saline (group 1) or insulin (3.5 U NPH daily) (group 2). Streptozo...
mentioned that chronic administration of the insulin-sensitising drugs, thiazolidinediones, results in low bone mineral density and fatty bones because MSC may differentiate towards adipogenesis rather than osteogenesis [3]. Thus, balanced osteoblastic and adipogenic differentiation is critical for the ...
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(1)为防止因迅速消化吸收引起的比较严重低血糖反应,因而应防止皮下注射NPH(中效胰岛素); (2)甘精胰岛素在大腿根部和屁股的消化吸收速率比较慢,因而当NPH做为基本甘精胰岛素时,其优选注入位置是大腿和屁股; (3)为减少夜间低血糖产生风险性,在很有可能的状况下,单用NPH应尽可能在临睡前给药,而防止在晚饭时给...