Several years' work with various classes of compounds using the technique of liquid chromatography/thermospray ionization mass spectrometry has given us the opportunity of observing further adduct ions of lower intensity. Knowledge about these ions facilitates interpretation of thermospray spectra, enables ...
In recent years, the matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been reported as an effective tool for the determination of GBS serotypes in a more rapid and accurate manner. Thus, this work aims to investigate GBS serotypes by incorporating...
在質譜分析中,控制實驗的能力極為重要。在謹慎控制的條件下產生離子後,必須以適當的靈敏度將離子當成離散事件進行偵測。GC所製造的蒸汽量極少,因此早期成為理想的串聯技術選擇,但只適用於約20%的化合物。如今,我們最常將LC沖提液霧化,當成在質譜儀中引入分析物進行游離的方法,這是一種必須以真空環境妥善控制的技術。
This technique has been successfully applied to characterize and chemically distinguish single cells of various neuron types from Aplysia californica. Here, hundreds of ions are detected within single-cell samples and 36 ions are identified. Furthermore, neuron-specific analytes are revealed, chemical ...
Enhanced adsorption of nicotinic acid by different types of Mg/Al layered double hydroxides: synthesis, equilibrium, kinetics, and thermodynamicsNicotinic acidadsorptionlayered double hydroxideion-exchangeMg/Al ratioThe aim of this study was to investigate the effect of different ions in the interlayer ...
To reveal the identity of the quinone cofactor and its position in the protein, the genes for QH-AmDH were cloned and sequenced, and the small subunit subjected to chemical analysis. The latter was carried out in a combination of automated Edman degradation, mass spectrometry, liquid chromatograp...
with target and qualifier ions and linear retention indices (Vandendool and Kratz, 1963) for each compound and from combinations of authentic standards, mass spectra comparisons to the NIST 2014 mass spectral library. An auto-tune of the GCMS was carried out before the analysis to ensure optimal...
a gene component constitutively, or differentially with respect to cell, the tissue or organ in which expression occurs or, with respect to the developmental stage at which expression occurs, or in response to external stimuli such as physiological stresses, pathogens, metal ions, or inducing ...
mass spectrometry (MS) analyses of HLA monoallelic cell lines modified to express ~25 amino acid segments corresponding to each of the 47 cancer neoantigens, resulting in 86 observed neoepitope–HLA pairs. To assess the therapeutic potential for these targets, we used TCRs discovered through ...
the application of small-molecule metabolites in the diagnosis of liver diseases was studied, and the pathogeneses of different liver diseases were further explored. In the early stage of this study, ultrafast liquid chromatography coupled with ion trap time-of-flight mass spectrometry (UFLC-IT-TOF...