To demonstrate the utility of SSAM, we analyzed published osmFISH data, where the transcripts of 33 cell-type marker genes were localized in 2D space of the mouse brain somatosensory cortex (SSp)6(Figs.2and3, Supplementary Figs.3and4). We compare results obtained from SSAM against the result...
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Pagetoid reticulosis histologically shows cytologically atypical mononuclear cells that exhibit epidermotropism with a clonal rearrangement of the beta T-cell receptor gene compared to folliculotrophic MF, which presents with alopecia because of the tumor infiltration of hair follicles with deposition of...
To better understand how this occurs, we performed single-cell transcriptomic profiling of young and old mouse brains after parabiosis. For each cell type, we cataloged alterations in gene expression, molecular pathways, transcriptional networks, ligand–receptor interactions and senescence status. Our ...
Lawyers and legal professionals can use PDF portfolios to keep track of anything related to a case or legal matter — correspondence threads, notes and records interviews and meetings, investigation reports, deposition documents, evidence and exhibits, briefs, transcripts, and so on. ...
We further implicate AtMYB41 in the production of aliphatic suberin under abiotic stress conditions. These results provide insight into the molecular-genetic mechanisms of the biosynthesis and deposition of a ubiquitous cell wall-associated plant structure and will serve as a basis for discovering the...
We investigated the effect of direct cell-cell contact between peripheral blood T lymphocytes or HUT-78 lymphoma cells and dermal fibroblasts or synoviocytes on the deposition of the major extracellular matrix components: types I and III collagen. Incubation of dermal fibroblasts and synoviocytes with ...
GO analysis of these DEGs revealed that cell proliferation-related transcripts were downregulated by APOE4, whereas neuron differentiation-associated genes were upregulated (Figure 2B). To investigate the possibility of different synaptic activity between APOE3- and APOE4-carrying neurons, we performed ...
MS response was shown to be temporally and spatially modulated by an intricate interplay of different signal transduction pathways, involving reactive oxygen species (ROS), hormones (indole acetic acid, gibberellins, ABA, and ethylene), and specific molecular factors regulating lignin deposition, cell ...
Keywords: keloid scar; fibrosis; mammalian target of rapamycin (mTOR); natural compound; flavonoid; silibinin 1. Introduction Keloid scars are fibroproliferative conditions characterized by the dysregulated pro- liferation of dermal fibroblasts and excessive deposition of extracellular matrix (ECM) ...