BLAST is a powerful tool for analyzing biological sequence data.Since the initial release of BLAST in 1990, it has undergone continuous updates to improve its speed and accuracy. BLAST is now considered a crucial and widely used tool in the field of bioinformatics. It has played a vital role ...
The DNA Data Bank of Japan (DDBJ) is another nucleotide database that exchanges data with GenBank and EMBL as a member of INSDC. DDBJ collects and exchanges nucleotide sequence data and manages bioinformatics tools for data submission and retrieval. It also develops tools for biological data anal...
Unfortunately, current bioinformatic tools use a great variety of heterogeneous formats./p pResults/p pAcknowledging the need for common formats, the Helmholtz Open BioInformatics Technology network (HOBIT) identified several basic data types used in bioinformatics and developed appropriate format ...
Bioinformatics data suggest that LINE-1 hypomethylation may affect expression of the genes that may contribute to the pathogenesis of SLE. However, additional functional studies of these proposed genes are warranted to prove this hypothesis. Journal of Human Genetics (2014) 59, 178–188; doi:...
Single cell technologies are rapidly generating large amounts of data that enables us to understand biological systems at single-cell resolution. However, joint analysis of datasets generated by independent labs remains challenging due to a lack of consi
(RVIS), gene intolerance scores based on the loss of function tool (LoFtool), variant types, and annotations from the OMIM database. We use variant types as features including missense, frameshift, nonframeshift, startloss, stopgain, and stoploss. We use the OMIM database to annotate the ...
Biological Databases- Types and Importance. A biological database is a large, organized body of persistent data, usually associated with computerized software designed to update, query, and retrieve components of the data stored within the system.
Figure: Primary Databases Examples. Image Source: Respective Database Websites. There are several primary sequence databases available that are widely used in the field of bioinformatics. The three main primary databases are GenBank at the National Center for Biotechnology Information (NCBI), the DNA...
Shedding light on DNA methylation and its clinical implications: the impact of long-read-based nanopore technology Alexandra Chera Mircea Stancu-Cretu Octavian Bucur Epigenetics & Chromatin(2024) Single-base resolution quantitative genome methylation analysis in the model bacterium Helicobacter pylori by enz...
A manually curated database of ligand-receptor pairs was generated from the CellChat mouse database and is provided in Supplementary Data 14. Chemokine genes considered for analysis were taken from MGI GO TERM “chemokine activity” [https://www.informatics.jax.org/go/term/GO:0008009]. scRNA-...