Pan-cancer classification of single cells in the tumour microenvironment Article Open access 23 March 2023 Main Cell-free RNA (cfRNA) represents a mixture of transcripts reflecting the health status of multiple tissues1, thereby affording broad clinical utility. Existing applications span oncology and...
Here, using vascular single-cell transcriptomics, we provide molecular definitions for the principal types of blood vascular and vessel-associated cells in the adult mouse brain. We uncover the transcriptional basis of the gradual phenotypic change (zonation) along the arteriovenous axis and reveal ...
cell, inbiology, the basic membrane-bound unit that contains the fundamental molecules of life and of which all living things are composed. A single cell is often a complete organism in itself, such as abacteriumoryeast. Other cellsacquirespecialized functions as they mature. These cells cooperat...
The Human Cell Atlas (HCA) is an international group of researchers using a combination of these new technologies to create cellular reference maps. The HCA use CL to annotated cells in their reference maps. Regev,A., Teichmann,S.A., Lander,E.S., Amit,I., Benoist,C., Birney,E., Bode...
R. Human intestinal M cells display the sialyl Lewis A antigen. Infect. Immun. 67, 946–953 (1999). Article CAS PubMed PubMed Central Google Scholar Buettner, M. & Lochner, M. Development and function of secondary and tertiary lymphoid organs in the small intestine and the colon. Front...
Stem cell, an undifferentiated cell that can divide to produce some offspring cells that continue as stem cells and some cells that are destined to differentiate (become specialized). Stem cells are an ongoing source of the differentiated cells that make
The targets of ascending sensory information in birds are clearly delimited nuclei that by circuitry resemble the input neurons of neocortical layer 4 (L4). Information output from the bird DT arises from cells in the arcopallium and the hyperpallium apicale (HA) (Figure 1, red nuclei), ...
cellular and molecular level, including the identification of progenitor cells, is a prerequisite for the development of novel therapeutic strategies. Recent advances in single-cell transcriptomics of the human lung have enabled the identification of new cell types, increased the understanding of ...
The major challenge of cell-based strategy lies in the determination of cell types on each cluster as multiple cells with different types are present in one cluster. As shown inFigure S1, cellular composition in each cluster could vary a lot. According to cell type annotation by SingleR, clust...
Single-cell RNA-sequencing (scRNA-seq) is a powerful technique that provides high-resolution expression profiling of individual cells. It significantly advances our understanding of cellular diversity and function. Despite its potential, the analysis of scRNA-seq data poses considerable challenges related...