Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. We extend this concept to identify cell types of origin using the Tabula Sapiens transcriptomic cell atlas as well as individual tissue transcriptomic cell atlases
The plasma membrane is responsible for monitoring the transport of nutrients and electrolytes in and out of the cells. It is also responsible for cell to cell communication. They reproduce sexually as well as asexually. There are some contrasting features between plant and animal cells. For eg....
Thin-film solar cells are made of films of photovoltaic (PV) materials, for example, silicon, cadmium, and copper. These types of solar cells are very easy to manufacture and are very cost-effective. Examples of second-generation solar cell materials include amorphous Si, thin-film Si, ...
Single-Cell RNA-SeqSpatial TranscriptomicsseqFISH+Tissue ArchitectureCellular CompositionCellularColocalizationIntercellular CommunicationDeep Neural NetworkSpatial organization of cell-types, their colocalization patterns, and intercellular communication mechanisms are critical aspects of brain architecture and fun...
Isolation and clonal assay of adult lung epithelial stem/progenitor cells. Curr. Protoc. Stem Cell Biol. 16, 2G.1.1-2G.1.12 (2011). Jin, S. et al. Inference and analysis of cell-cell communication using CellChat. Nat. Commun. 12, 1088 (2021). Article ADS CAS PubMed PubMed Central ...
We dene an extension of the -calculus which supports extended patterns of communication, such as client-server protocols. We then present a static type system for the language which allows concise high-level specications of these protocols. The channels on which the constituent communications of the...
The prefrontal cortex maintains information in memory through static or dynamic population codes depending on task demands, but whether the population coding schemes used are learning-dependent and differ between cell types is currently unknown. We inves
Here, using vascular single-cell transcriptomics, we provide molecular definitions for the principal types of blood vascular and vessel-associated cells in the adult mouse brain. We uncover the transcriptional basis of the gradual phenotypic change (zonation) along the arteriovenous axis and reveal ...
Cerebral cavernous malformation (CCM) is a hemorrhagic neurovascular disease with no currently available therapeutics. Prior evidence suggests that different cell types may play a role in CCM pathogenesis. The contribution of each cell type to the dysfun
Single-cell RNA-seq (scRNASeq) has become a powerful technique for measuring the transcriptome of individual cells. Unlike the bulk measurements that average the gene expressions over the individual cells, gene measurements at individual cells can be used to study several different tissues and organs...