There are over 200 different cell types in the human body. Each type of cells is specialised to carry out a particular function, either solely, but usually by forming a particular tissue. Different tissues then combine and form specific organs, where the organ is like a factory where every ...
In a mature organism, tissue homeostasis is regulated by cell division and cell demise as the two major physiological procedures. There is increasing evide
These interactions include (A) NOTCH, (B) EphB4/EphrinB2 and (C) endothelial cell adhesion molecules. The significant results of LR interactions were defined as p < 0.05, FDR corrected. The list of ligand-receptor interactions among all the cell types is available in Table S9 Full size...
Production of HO1 primed by pharmacological agents or gene transfer of human HO1 into endothelial cells in vitro fosters the cell cycle progression and attenuates the effect of angiotensin-2 and DNA damage caused by TNF and heme; in vivo administration corrects blood pressure elevation triggered by...
Future studies should examine the specific niches supporting the two HSC types in the FL and BM for BMP production, and examine whether other signalling molecules regulate the non-BMP-activated HSCs. Deciphering the behaviour and lineage output of HSCs during ontogeny, understanding whether the two ...
Random partitioning of molecules at cell division. Proc. Natl Acad. Sci. USA 108, 15004–15009 (2011). Article CAS PubMed PubMed Central Google Scholar Mohler, K. & Ibba, M. Translational fidelity and mistranslation in the cellular response to stress. Nat. Microbiol. 2, 17117 (2017). ...
Single-cell genomic methods now provide unprecedented resolution for characterizing the component cell types and states of tissues such as the epithelial subsets of the gastrointestinal tract. Nevertheless, functional studies of these subsets at scale re
Cell signallingSignalling molecule gradientPolymeric materialThe ability to control spatial arrangement and geometry of different cell types while keeping them separated and in close proximity for a long time is crucial to mimic and study variety of biological processes in聽vitro. Although the existing ...
Cerebral cavernous malformation (CCM) is a hemorrhagic neurovascular disease with no currently available therapeutics. Prior evidence suggests that different cell types may play a role in CCM pathogenesis. The contribution of each cell type to the dysfun
Our study, demonstrates the particular inflammation and immunity characteristics of RDEB adults, with activated / effector T and dysfunctional natural killer cell signatures, concomitant with an overall pro-inflammatory lipid signature. Artificial intelligence prediction models and principal component analysis ...