Brain atrophy, also referred to as cerebral atrophy, refers to the reduction in the size of the brain. Several conditions can cause a brain to atrophy, including diseases and aging. The various types of cerebral atrophy include those classified as generalized and those classified as focal. ...
We used brain single-cell data28 to define brain cell type gene profiles in both the AD and the normal brain. Several DEGs found in cfRNA analysis of AD plasma are brain cell type specific (P < 10−5, hypergeometric test). Astrocyte-specific genes include those that encode filament...
Ependymal cells produce CSF (cerebrospinal fluid), which is located within the ventricles of the brain and in the subarachnoid space that surrounds the brain and spinal cord. Aside from allowing the brain to float in the skull, CSF acts as a cushion against traumaand also helps wash away some...
Multiple system atrophy also usually progresses much faster than Parkinson’s disease.Like Parkinson’s disease, multiple system atrophy typically is marked by toxic clumps of the protein alpha-synuclein in the brain. Formerly, multiple system atrophy has been known as Shy-Drager syndrome, olivoponto...
Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcrip
Although SARS-CoV-2 primarily targets the respiratory system, patients with and survivors of COVID-19 can suffer neurological symptoms1–3. However, an unbiased understanding of the cellular and molecular processes that are affected in the brains of pati
Visualization,quantification and correlation of brain atrophy with clinical symptoms in spinocerebellar ataxia types1,3and6. Schulz JB,Borkert J,Wolf S,et al. Neuroimage . 2010Schulz, J.B., Borkert, J., Wolf, S., Schmitz-Hubsch, T., Rakowicz, M., Mariotti, C., Schols, L., Timmann...
While it remains unclear whether these factors originate from senescent cells in the central nervous system (CNS) or peripheral blood and tissues, they suggest the presence of senescent cell accumulation in patients. This section reviews current evidence linking brain cell senescence to AD pathology, ...
A child with this type of SMA might have breathing problems, especially when they’re asleep. Depending on how bad symptoms are, their life span might be shorter than normal. Type 3 Children with this type usually begin to have symptoms between 18 months old and their teens. It’s also ...
This form is much less common than ALS or PBP. It can be inherited or sporadic. Progressive muscular atrophy mainly affects your lower motor neurons. Weakness usually starts in your hands and then spreads to other parts of the body. Your muscles get weak and may cramp. This disease can tur...