osteoporosis is a common disease of bone possessing a strong genetic component. Cytochrome P450 aromatase, which is encoded by the CYP19Al gene, converts androgens to estradiol. Considerable evidence suggests that extragonadal estrogens play an important role in determining bone mineral density (BMD)...
Some people with multiple myeloma don't make enough M proteins or light chains for tests to show they have it. This is called non-secretory myeloma. A bone marrow biopsy can help diagnose this type of myeloma. 3. Solitary Plasmacytoma When plasma cells become cancerous and grow out of cont...
Aplastic anemia is a life-threatening form of complete bone marrow failure. As a result, the blood contains inadequate numbers of red blood cells (anemia) as well as insufficient white blood cells (leukopenia) and platelets (thrombocytopenia). Complete bone marrow failure causes all three cell lin...
These are cells in your blood and bone marrow that haven’t matured into their final form. The doctor uses them to replace cells in your bone marrow that other treatments kill. That means you can get higher doses of those therapies. Sometimes, stem cells can find and kill cancer cells. ...
Neuroblastomain children develops in the immature nerve tissues that form the sympathetic nervous system. It usually affects the adrenal glands inside the abdomen. The disease is common in babies and children under the age of 5. Sarcomais a cancer that develops in the bone or s...
Side effects: Gold salts must be used with caution in people with liver or kidney diseaseand those with a history of bone marrow disease or severe hypertension. Skin rash and irritation are common side effects. Gold salts may cause the following: ...
Read about types of bone fracture (broken bones). The most common broken bones are stress fractures, rib fractures, skull fractures, hip fractures, and fractures in children. Causes vary and treatment is dependent upon the type of fracture.
Chronic myelogenous leukemia (CML) is known as a myeloproliferative disorder — that is, it is a disease in which bone marrow cells multiply outside of the bone marrow tissue. CML has a genetic marker or peculiarity that makes it somewhat easy to diagnose. However, while CML is easy to dia...
Aplastic anemia is a form of anemia (low blood counts) that happens when your bone marrow can't make enough blood cells. It can affect one or many different blood cell types to cause a wide range of symptoms. You can get treatment to help address the causes of your aplastic anemia or ...
CRISPR gene editing for sickle cell disease In December 2023, the FDA approved two gene therapy treatments for sickle cell disease. The two therapies, Casgevy and Lyfgenia, both work by modifying stem cells taken from bone marrow, the spongy inside of bones. These stem cells are then modified...