osteoporosis is a common disease of bone possessing a strong genetic component. Cytochrome P450 aromatase, which is encoded by the CYP19Al gene, converts androgens to estradiol. Considerable evidence suggests t
What is bone marrow disease? What type of stem cells are found in bone marrow? What are bone marrow stem cells? What is normocellular bone marrow? What is another name for bone marrow? What do stem cells do in bone marrow? What type of cells are produced by red bone marrow?
Aplastic anemia is a life-threatening form of complete bone marrow failure. As a result, the blood contains inadequate numbers of red blood cells (anemia) as well as insufficient white blood cells (leukopenia) and platelets (thrombocytopenia). Complete bone marrow failure causes all three cell lin...
8. Immunoglobulin E (IgE) Myeloma IgE is the rarest type of multiple myeloma. It causes the same signs and symptoms as other types of multiple myeloma. It tends to be aggressive and progresses to plasma cellleukemiaor spreads outside the bone marrow quickly....
Endotypes are characterized by the immunological, inflammatory, metabolic, and remodelling pathways that explain the mechanisms underlying the clinical presentation (phenotype) of a disease. Recessive dystrophic epidermolysis bullosa (RDEB) is a severe b
Inflammasomes are defense complexes that utilize cytokines and immunogenic cell death (ICD) to stimulate the immune system against pathogens. Inspired by their dual action, we present cytokine-armed pyroptosis as a strategy for boosting immune response a
CRISPR gene editing for sickle cell disease In December 2023, the FDA approved two gene therapy treatments for sickle cell disease. The two therapies, Casgevy and Lyfgenia, both work by modifying stem cells taken from bone marrow, the spongy inside of bones. These stem cells are then modified...
Long-term results of spinal cord injury therapy using mesenchymal stem cells derived from bone marrow in humans 2012, Neurosurgery Mesenchymal stem cells and their use as cell replacement therapy and disease modelling tool 2008, Journal of Cellular and Molecular Medicine A hypothesis for an embryonic...
Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transpl. 2013;48:452–458. Article CAS Google Scholar Armand P, Kim HT, Logan BR, Wang Z, Alyea EP, Kalaycio ME, et al. Validation and refinement of the Disease Risk Index...
Cell-free RNA (cfRNA) represents a mixture of transcripts reflecting the health status of multiple tissues1, thereby affording broad clinical utility. Existing applications span oncology and bone marrow transplantation2,3, obstetrics1,4,5, neurodegeneration6 and liver disease7. However, several aspects...