The most dramatic discovery of this type is due to Pierre Paul Broca, who proclaimed in 1864: "we speak with the left hemisphere". Indeed, he was able to establish that damage in an area of the left posterior frontal lobe, which was later called Broca's area, yields the so-calledBroca...
Bipolar used to be calledmanic depression. Bipolar disorder is very serious and can cause risky behaviour, even suicidal tendencies. According to the NHS, about one person in every 100 in the UK is diagnosed with a bipolar disorder. There are different types of bipolar disorder, including type ...
Bipolar disorderis a mood disorder that results in large mood swings. Those with this bipolar depression will experience periods of mania (extreme highs) that often alternate with depressive periods (extreme lows). There is an increased risk of suicide with bipolar disorder, and those who have th...
Studies in other populations, such as individuals with an intellectual disability (Tournier et al., 2021) and individuals with long-lasting mental health conditions such as schizophrenia or bipolar disorder (Sweet et al., 2018), have been able to distinguish typologies of social networks with ...
Notably, the conventional diagnoses [schizophrenia (SZ), schizoaffective disorder (SAD), psychotic bipolar I disorder (BD)] mapped poorly onto the Biotypes, with all three diagnoses distributed across all Biotypes. Analysis of whole brain voxel-wise morphometry—an “external validator” not used...
et al. The brainstem pathologies of Parkinson’s disease and dementia with Lewy bodies. Brain Pathol. 25, 121–135 (2015). Article PubMed Google Scholar Stahl, E. A. et al. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nat. Genet. 51, 793–803 (...
(Alzheimer’s disease, amyotrophic lateral sclerosis, brain ageing, multiple system atrophy, multiple sclerosis, Parkinson’s disease and narcolepsy), psychiatric disorders (attention deficit hyperactivity disorder, autism, bipolar disorder, depression, psychosis, post-traumatic stress disorder and ...
Summary statistics from a recent genome-wide association study of chronotype were used to identify SNPs associated with chronotype using UK Biobank data from Jones et al. (16) (N = 449,734); summary statistics from 23andMe data were not available for this study. To provide a benchmark for ...
Serum concentrations of high-sensitivity CRP (mg/L) were analysed at the Royal Victoria Infirmary laboratory in Newcastle (UK), using the N Latex CRP mono Immunoassay on the Behring Nephelometer II Analyser48. CRP values were log-transformed due to their initially skewed distribution. Statistical ...
Centromeres are the chromosomal domains required to ensure faithful transmission of the genome during cell division. They have a central role in preventing aneuploidy, by orchestrating the assembly of several components required for chromosome separation