Studies in other populations, such as individuals with an intellectual disability (Tournier et al., 2021) and individuals with long-lasting mental health conditions such as schizophrenia or bipolar disorder (Sweet et al., 2018), have been able to distinguish typologies of social networks with ...
The most dramatic discovery of this type is due to Pierre Paul Broca, who proclaimed in 1864: "we speak with the left hemisphere". Indeed, he was able to establish that damage in an area of the left posterior frontal lobe, which was later called Broca's area, yields the so-calledBroca...
Types of anxiety disorder There are many different types of anxiety disorder, defined and distinguished from each other by the situations or other triggers that lead to extreme feelings of fear or worry.[1]The most common types of anxiety disorders are described below. In all cases, the sympto...
Manic depression or as it’s more commonly known, bipolar disorder, is a mental health condition that causes extreme mood changes. Those with bipolar disorder have episodes of depression, where they feel very low, hopeless and lethargic and then episodes of mania where they feel very happy, ful...
Notably, the conventional diagnoses [schizophrenia (SZ), schizoaffective disorder (SAD), psychotic bipolar I disorder (BD)] mapped poorly onto the Biotypes, with all three diagnoses distributed across all Biotypes. Analysis of whole brain voxel-wise morphometry—an “external validator” not used...
Serum concentrations of high-sensitivity CRP (mg/L) were analysed at the Royal Victoria Infirmary laboratory in Newcastle (UK), using the N Latex CRP mono Immunoassay on the Behring Nephelometer II Analyser48. CRP values were log-transformed due to their initially skewed distribution. Statistical ...
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For example, we estimated that AUC for distinguishing schizophrenia from major depressive disorder (MDD), bipolar disorder (BPD) from MDD and schizophrenia from BPD were 0.694, 0.602 and 0.618, respectively, while the maximum AUC (based on h snp ) were 0.763, 0.749 and 0.726, respectively. We...
et al. The brainstem pathologies of Parkinson’s disease and dementia with Lewy bodies. Brain Pathol. 25, 121–135 (2015). Article PubMed Google Scholar Stahl, E. A. et al. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nat. Genet. 51, 793–803 (...
Centromeres are the chromosomal domains required to ensure faithful transmission of the genome during cell division. They have a central role in preventing aneuploidy, by orchestrating the assembly of several components required for chromosome separation